Grape polyphenols reduce fasting glucose and increase hyocholic acid in healthy humans - a meta-omics study

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Mezhibovsky, Esther, Wu, Guojun, Wu, Yue, Ning, Zhibin, Bacalia, Karen, Sadangi, Sriya, Patel, Riddhi, Poulev, Alexander, Duran, Rocio M., Macor, Marie, Coyle, Susette, Lam, Yan Y., Raskin, Ilya, Figeys, Daniel ORCID: https://orcid.org/0000-0002-5373-7546, Zhao, Liping and Roopchand, Diana E. (2025) Grape polyphenols reduce fasting glucose and increase hyocholic acid in healthy humans - a meta-omics study. npj Science of Food, 9 (1). ISSN 2396-8370

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Abstract

Grape polyphenols (GPs) are rich in B-type proanthocyanidins, which promote metabolic resilience. Longitudinal metabolomic, metagenomic, and metaproteomic changes were measured in 27 healthy subjects supplemented with soy protein isolate (SPI, 40 g per day) for 5 days followed by GPs complexed to SPI (GP-SPI standardized to 5% GPs, 40 g per day) for 10 days. Fecal, urine, and/or fasting blood samples were collected before supplementation (day –5), after 5 days of SPI (day 0), and after 2, 4 and 10 days of GP-SPI. Most multi-omic changes observed after 2 and/or 4 days of GP-SPI intake were temporary, returning to pre-supplementation profiles by day 10. Shotgun metagenomics sequencing provided insights that could not be captured with 16S rRNA amplicon sequencing. Notably, 10 days of GP-SPI decreased fasting blood glucose and increased serum hyocholic acid (HCA), a glucoregulatory bile acid, which negatively correlated with one gut bacterial guild. In conclusion, GP-induced suppression of a bacterial guild may lead to higher HCA and lower fasting blood glucose.

Item Type: Article
Uncontrolled Keywords: food science,public health, environmental and occupational health,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1100/1106
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 23 Jul 2025 14:30
Last Modified: 18 Jun 2026 20:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/99984
DOI: 10.1038/s41538-025-00443-6

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