Grape polyphenols reduce fasting glucose and increase hyocholic acid in healthy humans - a meta-omics study

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Mezhibovsky, Esther, Wu, Guojun, Wu, Yue, Ning, Zhibin, Bacalia, Karen, Sadangi, Sriya, Patel, Riddhi, Poulev, Alexander, Duran, Rocio M., Macor, Marie, Coyle, Susette, Lam, Yan Y., Raskin, Ilya, Figeys, Daniel, Zhao, Liping and Roopchand, Diana E. (2025) Grape polyphenols reduce fasting glucose and increase hyocholic acid in healthy humans - a meta-omics study. npj Science of Food, 9 (1). ISSN 2396-8370

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Abstract

Grape polyphenols (GPs) are rich in B-type proanthocyanidins, which promote metabolic resilience. Longitudinal metabolomic, metagenomic, and metaproteomic changes were measured in 27 healthy subjects supplemented with soy protein isolate (SPI, 40 g per day) for 5 days followed by GPs complexed to SPI (GP-SPI standardized to 5% GPs, 40 g per day) for 10 days. Fecal, urine, and/or fasting blood samples were collected before supplementation (day –5), after 5 days of SPI (day 0), and after 2, 4 and 10 days of GP-SPI. Most multi-omic changes observed after 2 and/or 4 days of GP-SPI intake were temporary, returning to pre-supplementation profiles by day 10. Shotgun metagenomics sequencing provided insights that could not be captured with 16S rRNA amplicon sequencing. Notably, 10 days of GP-SPI decreased fasting blood glucose and increased serum hyocholic acid (HCA), a glucoregulatory bile acid, which negatively correlated with one gut bacterial guild. In conclusion, GP-induced suppression of a bacterial guild may lead to higher HCA and lower fasting blood glucose.

Item Type: Article
Uncontrolled Keywords: food science,public health, environmental and occupational health,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1100/1106
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 23 Jul 2025 14:30
Last Modified: 14 Aug 2025 01:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/99984
DOI: 10.1038/s41538-025-00443-6

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