Therapeutic Potential of Cranberry Proanthocyanidins in Addressing the Pathophysiology of Metabolic Syndrome - A Scrutiny of Select Mechanisms of Action

Feldman, Francis, Koudoufio, Mireille, Sané, Alain Théophile, Marcil, Valérie, Sauvé, Mathilde Foisy, Butcher, James, Patey, Natalie, Martel, Catherine, Spahis, Schohraya, Duan, Haonan, Figeys, Daniel, Desjardins, Yves, Stintzi, Alain and Levy, Emile (2025) Therapeutic Potential of Cranberry Proanthocyanidins in Addressing the Pathophysiology of Metabolic Syndrome - A Scrutiny of Select Mechanisms of Action. Antioxidants, 14 (3). ISSN 2076-3921

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Abstract

Metabolic syndrome (MetS) constitutes a spectrum of interconnected conditions comprising obesity, dyslipidemia, hypertension, and insulin resistance (IR). While a singular, all-encompassing treatment for MetS remains elusive, an integrative approach involving tailored lifestyle modifications and emerging functional food therapies holds promise in preventing its multifaceted manifestations. Our main objective was to scrutinize the efficacy of cranberry proanthocyanidins (PAC, 200 mg/kg/day for 12 weeks) in mitigating MetS pathophysiology in male mice subjected to standard Chow or high-fat/high-fructose (HFHF) diets while unravelling intricate mechanisms. The administration of PAC, in conjunction with an HFHF diet, significantly averted obesity, evidenced by reductions in body weight, adiposity across various fat depots, and adipocyte hypertrophy. Similarly, PAC prevented HFHF-induced hyperglycemia and hyperinsulinemia while also lessening IR. Furthermore, PAC proved effective in alleviating key risk factors associated with cardiovascular diseases by diminishing plasma saturated fatty acids, as well as levels of triglycerides, cholesterol, and non-HDL-C levels. The rise in adiponectin and drop in circulating levels of inflammatory markers showcased PAC’s protective role against inflammation. To better clarify the mechanisms behind PAC actions, gut–liver axis parameters were examined, showing significant enhancements in gut microbiota composition, microbiota-derived metabolites, and marked reductions in intestinal and hepatic inflammation, liver steatosis, and key biomarkers associated with endoplasmic reticulum (ER) stress and lipid metabolism. This study enhances our understanding of the complex mechanisms underlying the development of MetS and provides valuable insights into how PAC may alleviate cardiometabolic dysfunction in HFHF mice.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2025 by the authors.
Uncontrolled Keywords:	dyslipidemia,gut–liver axis,hepatic steatosis,inflammation,intestinal microbiota,obesity,food science,physiology,biochemistry,molecular biology,clinical biochemistry,cell biology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1100/1106
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	23 Jul 2025 14:30
Last Modified:	18 Aug 2025 00:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99981
DOI:	10.3390/antiox14030268

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