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ToolsGobbi, Cecilia, Giangiacomi, Francesco, Merinopoulos, Ioannis, Gherbesi, Elisa, Faggiano, Andrea, Pasero, Guido, Barbieri, Lucia, Tumminello, Gabriele, Colombo, Federico, Mircoli, Luca, Ruscica, Massimiliano, Vassiliou, Vassilios S., Eccleshall, Simon C. and Carugo, Stefano (2025) Drug coated balloon angioplasty for de novo coronary lesions in large vessels: A systematic review and meta-analysis. Scientific Reports, 15. ISSN 2045-2322
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Abstract
We aimed to investigate the safety of drug-coated balloon (DCB)-only percutaneous coronary intervention compared to drug-eluting stent (DES) for de novo lesions in large vessels. To pursue this goal, we conducted a systematic review and meta-analysis following the PRISMA guidelines. The analysis included studies that utilized DCB-only or hybrid angioplasty for de novo lesions in large coronary vessel (> 2.75 mm). The primary outcome was to assess the target lesion revascularization (TLR) rate, while secondary outcomes included cardiac death, myocardial infarction (MI), and the composite of these. A total of 15 studies, comprising 3975 patients (of whom 2114 treated with DCB) were included. Median age was 62 ± 1.5 years, with 77.4% being male. Overall, 26.9% had diabetes, and 67.6% were diagnosed with acute coronary syndrome. Over a pooled follow-up of 20.6 ± 1.9 months, the incidence of TLR was 4% in the pooled DBC group. Additionally, over a pooled follow-up of 25.8 ± 2.7 months, no significant differences were observed in incidence of TLR between the DCB group and the DES group (4.3% vs. 6.9%, odds ratio 0.71, 95% confidence interval 0.50–1.01, p = 0.059). Furthermore, there were no differences in incidence of cardiac death and MI. DCB angioplasty treatment of de novo lesions in large coronary vessels could be a safe and effective strategy in both acute and chronic coronary settings. The incidence of target lesion revascularization appears to be similar to that of contemporary DES.
| Item Type: | Article |
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| Additional Information: | Data availability statement: The datasets used and analysed during the current study are available from the corresponding author on reasonable request. Funding information: This work was partially supported by Ministero dell’Università e della Ricerca (Progetti di Rilevante Interesse Nazionale 2022ZPS49L) to MR and SC; by Italian Ministry of Health, Ricerca Corrente 2025 Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (to SC) and by the European Union—Next Generation EU, Italian National Recovery and Resilience Plan, (Mission 4, Component 2, Investment 1.5 “Innovation Ecosystems”), project MUSA (to SC and MR). |
| Uncontrolled Keywords: | acute coronary syndrome,drug-coated balloon,drug-eluting stent,target lesion revascularization,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Jul 2025 08:30 |
| Last Modified: | 14 Jul 2025 12:33 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/99796 |
| DOI: | 10.1038/s41598-025-85734-4 |
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