Tools
Tools
Phillips, John, Murdin, Louisa, Khondoker, Mizanur 
ORCID: https://orcid.org/0000-0002-1801-1635, Grant, Kelly, Shepstone, Lee, Sims, Erika ORCID: https://orcid.org/0000-0002-7898-0331, Rea, Peter and Harcourt, Jonny
(2024)
Cluster analysis to identify clinical subtypes of Ménière's disease.
Laryngoscope, 134 (7).
pp. 3286-3292.
ISSN 0023-852X
Preview |
PDF (Cluster MDR MAIN_Text_Tables_Figures)
- Accepted Version
Download (403kB) | Preview |
Abstract
Objective: To identify distinct clinical subtypes of Ménière's disease by analyzing data acquired from a UK registry of patients who have been diagnosed with Ménière's disease. Study Design: Observational study. Methods: Patients with Ménière's disease were identified at secondary/tertiary care clinics. Cluster analysis was performed by grouping participants sharing similar characteristics and risk factors into groups based on a defined measure of similarity. Results: A total of 411 participants were recruited into this study. Two main clusters were identified: participants diagnosed with ear infections (OR = 0.30, p < 0.014, 95% CI: 0.11–0.78) were more likely to be allocated in Cluster 1 (C1). Participants reporting tinnitus in both ears (OR = 11.89, p < 0.001, 95% CI: 4.08–34.64), low pitched tinnitus (OR = 21.09, p < 0.001, 95% CI: 7.47–59.54), and those reporting stress as a trigger for vertigo attacks (OR = 14.94, p < 0.001, 95% CI: 4.54–49.10) were significantly more likely to be in Cluster 2 (C2). Also, participants diagnosed with Benign Paroxysmal Positional Vertigo (OR = 13.14, <0.001, 95% CI: 4.35–39.74), autoimmune disease (OR = 5.97, p < 0.007, 95% CI: 1.62–22.03), depression (OR = 4.72, p < 0.056, 95% CI: 0.96–23.24), migraines (OR = 3.13, p < 0.008, 95% CI: 1.34–7.26), drug allergy (OR = 3.25, p < 0.029, 95% CI: 1.13–9.34), and hay fever (OR = 3.12, p < 0.009, 95% CI: 1.33–7.34) were significantly more likely to be clustered in C2. Conclusions: This study supports the hypothesis that Ménière's disease is a heterogeneous condition with subgroups that may be identifiable by clinical features. Two main clusters were identified with differing putative etiological factors. Level of Evidence: 3 Laryngoscope, 134:3286–3292, 2024.
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |