Cluster analysis to identify clinical subtypes of Ménière's disease

Phillips, John, Murdin, Louisa, Khondoker, Mizanur, Grant, Kelly, Shepstone, Lee, Sims, Erika, Rea, Peter and Harcourt, Jonny (2024) Cluster analysis to identify clinical subtypes of Ménière's disease. Laryngoscope, 134 (7). pp. 3286-3292. ISSN 0023-852X

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Abstract

Objective: To identify distinct clinical subtypes of Ménière's disease by analyzing data acquired from a UK registry of patients who have been diagnosed with Ménière's disease. Study Design: Observational study. Methods: Patients with Ménière's disease were identified at secondary/tertiary care clinics. Cluster analysis was performed by grouping participants sharing similar characteristics and risk factors into groups based on a defined measure of similarity. Results: A total of 411 participants were recruited into this study. Two main clusters were identified: participants diagnosed with ear infections (OR = 0.30, p < 0.014, 95% CI: 0.11–0.78) were more likely to be allocated in Cluster 1 (C1). Participants reporting tinnitus in both ears (OR = 11.89, p < 0.001, 95% CI: 4.08–34.64), low pitched tinnitus (OR = 21.09, p < 0.001, 95% CI: 7.47–59.54), and those reporting stress as a trigger for vertigo attacks (OR = 14.94, p < 0.001, 95% CI: 4.54–49.10) were significantly more likely to be in Cluster 2 (C2). Also, participants diagnosed with Benign Paroxysmal Positional Vertigo (OR = 13.14, <0.001, 95% CI: 4.35–39.74), autoimmune disease (OR = 5.97, p < 0.007, 95% CI: 1.62–22.03), depression (OR = 4.72, p < 0.056, 95% CI: 0.96–23.24), migraines (OR = 3.13, p < 0.008, 95% CI: 1.34–7.26), drug allergy (OR = 3.25, p < 0.029, 95% CI: 1.13–9.34), and hay fever (OR = 3.12, p < 0.009, 95% CI: 1.33–7.34) were significantly more likely to be clustered in C2. Conclusions: This study supports the hypothesis that Ménière's disease is a heterogeneous condition with subgroups that may be identifiable by clinical features. Two main clusters were identified with differing putative etiological factors. Level of Evidence: 3 Laryngoscope, 134:3286–3292, 2024.

Item Type:	Article
Uncontrolled Keywords:	clinical subtyping,intratympanic steroids,meniere's disease,otorhinolaryngology ,/dk/atira/pure/subjectarea/asjc/2700/2733
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Science > Research Groups > Statistics Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	25 Jun 2025 16:30
Last Modified:	25 Jun 2025 16:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99724
DOI:	10.1002/lary.31272

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