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ToolsMei, Youwen, Yu, Jiaxiao, Wen, Li, Fan, Xin, Zhao, Yan, Li, Jie, Qiao, Juan, Fu, Huijia, Leong, Pamela, Saffery, Richard, Tong, Qi, Kilby, Mark D., Qi, Hongbo, Tong, Chao and Baker, Philip N. (2020) Perinatal outcomes and offspring growth profiles in twin pregnancies complicated by gestational diabetes mellitus:A longitudinal cohort study. Diabetes Research and Clinical Practice, 171. ISSN 0168-8227
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Abstract
Aims: To evaluate the influence of gestational diabetes mellitus (GDM) on the perinatal outcomes of twin pregnancies and its impact on fetal growth profiles of twin offspring from 6 weeks to 12 months of corrected age. Methods: A longitudinal cohort study was conducted among pregnant women with twins and their twin offspring. All information on perinatal outcomes and child growth trajectories from 6 weeks to 12 months of corrected age were obtained and analyzed using a general linear model and logistic regression models. Results: GDM was not correlated with adverse perinatal outcomes of twin pregnancies; however, in monochorionic diamniotic (MCDA), but not dichorionic diamniotic (DCDA) twin pregnancies, GDM was correlated with gestational hypertension disorder and a fetus being small for gestational age (OR, 2.68; 95% CI 1.16–6.04 and OR, 0.35; 95% CI 0.16–0.76, respectively). In both MCDA and DCDA groups, GDM was positively associated with a higher risk of childhood overweight at 6 months of corrected age (2.32 [1.05, 5.09] and 2.00 [1.13, 3.53]). Conclusions: GDM had a greater impact on MCDA twin pregnancies in terms of maternal gestational hypertension disease and small for gestational age of newborns. Additionally, twin offspring exposed to GDM had a higher risk of being overweight at 6 months of corrected age irrespective of chorionicity. Clinical Trial Registration: ChiCTR-OOC-16008203.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2020 Elsevier B.V. |
| Uncontrolled Keywords: | gestational diabetes mellitus,offspring growth profiles,perinatal outcomes,twin pregnancies,internal medicine,endocrinology, diabetes and metabolism,endocrinology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2724 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 24 Jun 2025 16:30 |
| Last Modified: | 24 Jun 2025 16:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/99706 |
| DOI: | 10.1016/j.diabres.2020.108623 |
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