Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia

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Peng, Wei, Tong, Chao, Li, Lei, Huang, Chengyu, Ran, Yuxin, Chen, Xuehai, Bai, Yuxiang, Liu, Yamin, Zhao, Jianlin, Tan, Bin, Luo, Xiaofang, Wang, Hao, Wen, Li, Zhang, Chen, Zhang, Hua, Ding, Yubin, Qi, Hongbo and Baker, Philip N. (2019) Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia. FASEB Journal, 33 (5). pp. 6327-6338. ISSN 0892-6638

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Abstract

Successful pregnancy requires normal placentation, which largely depends on the tight regulation of proliferation, invasion, and migration of trophoblast cells. Abnormal functioning of trophoblast cells may cause failure of uterine spiral artery remodeling, which may be related to pregnancy-related disorders, such as preeclampsia. Here, we reported that an actin-binding protein, α-actinin (ACTN)4, was dysregulated in placentas from early onset preeclampsia. Moreover, knockdown of ACTN4 markedly inhibited trophoblast cell proliferation by reducing AKT membrane translocation. Furthermore, E-cadherin regulated ACTN4 and β-catenin colocalization on trophoblast cell podosomes, and ACTN4 down-regulation suppressed the E-cadherin-induced cell invasion increase via depolymerizing actin filaments. Moreover, loss of ACTN4 recapitulated a number of the features of human preeclampsia. Therefore, our data indicate that ACNT4 plays a role in trophoblast function and is required for normal placental development.—Peng, W., Tong, C., Li, L., Huang, C., Ran, Y., Chen, X., Bai, Y., Liu, Y., Zhao, J., Tan, B., Luo, X., Wang, H., Wen, L., Zhang, C., Zhang, H., Ding, Y., Qi, H., Baker, P. N. Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia. FASEB J. 33, 6327–6338 (2019). www.fasebj.org.

Item Type:	Article
Uncontrolled Keywords:	akt,migration,placenta,podosome,biotechnology,biochemistry,molecular biology,genetics ,/dk/atira/pure/subjectarea/asjc/1300/1305
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	23 Jun 2025 16:30
Last Modified:	24 Jun 2025 13:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99681
DOI:	10.1096/fj.201802058RR

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