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ToolsMayrink, Jussara, Souza, Renato T., Feitosa, Francisco E., Rocha Filho, Edilberto A., Leite, Débora F., Vettorazzi, Janete, Calderon, Iracema M., Costa, Maria L., Kenny, Louise, Baker, Philip and Cecatti, Jose G. and The Preterm SAMBA study group (2019) Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant women. BMC Pregnancy and Childbirth, 19. ISSN 1471-2393
Full text not available from this repository. (Request a copy)Abstract
Background: Prediction of preeclampsia is a challenge to overcome. The vast majority of prospective studies in large general obstetric populations have failed in the purpose of obtain a useful and effective model of prediction, sometimes based on complex tools unavaible in areas where the incidence of preeclampsia is the highest. The goal of this study was to assess mean arterial blood pressure (MAP) levels at 19-21, 27-29 and 37-39 weeks of gestation and performance of screening by MAP for the prediction of preeclampsia in a Brazilian cohort of healthy nulliparous pregnant women. Methods: This was a cohort approach to a secondary analysis of the Preterm SAMBA study. Mean arterial blood pressure was evaluated at three different time periods during pregnancy. Groups with early-onset preeclampsia, late-onset preeclampsia and normotension were compared. Increments in mean arterial blood pressure between 20 and 27 weeks and 20 and 37 weeks of gestation were also calculated for the three groups studied. The accuracy of mean arterial blood pressure in the prediction of preeclampsia was determined by ROC curves. Results: Of the 1373 participants enrolled, complete data were available for 1165. The incidence of preeclampsia was 7.5%. Women with early-onset preeclampsia had higher mean arterial blood pressure levels at 20 weeks of gestation, compared to the normotensive group. Women with late-onset preeclampsia had higher mean arterial blood pressure levels at 37 weeks of gestation, than the normotensive groups and higher increases in this marker between 20 and 37 weeks of gestation. Based on ROC curves, the predictive performance of mean arterial blood pressure was higher at 37 weeks of gestation, with an area under the curve of 0.771. Conclusion: As an isolated marker for the prediction of preeclampsia, the performance of mean arterial blood pressure was low in a healthy nulliparous pregnant women group. Considering that early-onset preeclampsia cases had higher mean arterial blood pressure levels at 20 weeks of gestation, future studies with larger cohorts that combine multiple markers are needed for the development of a preeclampsia prediction model.
| Item Type: | Article |
|---|---|
| Additional Information: | Availability of data and materials: The datasets generated and analysed during the current research are available from the corresponding author on reasonable request. The participating women did not give their consent to make their own data publicly available. Funding: This study was funded by the Bill and Melinda Gates Foundation, Seatle, WA (grant OPP1107597) and CNPq, Brazil (grant 401636/2013–5). The funders did not influence the study, including development, data collection, data analysis or data interpretation. |
| Uncontrolled Keywords: | blood pressure,hypertension,preeclampsia,prenatal screening,second trimester,third trimester,obstetrics and gynaecology ,/dk/atira/pure/subjectarea/asjc/2700/2729 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 23 Jun 2025 12:30 |
| Last Modified: | 23 Jun 2025 12:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/99666 |
| DOI: | 10.1186/s12884-019-2580-4 |
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