Five serum fatty acids are associated with subclinical hypothyroidism in a Chinese pregnant population

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Zhang, Ting, Xia, Yinyin, Han, Ting Li, Zhang, Hua and Baker, Philip N. (2020) Five serum fatty acids are associated with subclinical hypothyroidism in a Chinese pregnant population. Scientific Reports, 10. ISSN 2045-2322

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Abstract

Subclinical hypothyroidism (SCH) is a common endocrine disorder affecting women of reproductive age. Although SCH and abnormal fatty acid composition are often associated with adverse pregnancy outcomes and metabolic syndrome later in maternal and fetal life, the longitudinal relationship between SCH and serum fatty acids during pregnancy has rarely been studied. Therefore, the aim of this study was to investigate the association between SCH and maternal serum fatty acids throughout gestation. A total of 240 women enrolled in the Complex Lipids in Mothers and Babies (CLIMB) study in Chongqing, China were included in our study. Clinical information and maternal serum samples were collected at three time points during pregnancy: 11–14th, 22–28th, and 32–34th weeks of gestation. Twenty serum fatty acids were quantified using gas chromatography-mass spectrometry (GC-MS) analysis. A majority of the 20 serum fatty acids increased as gestation progressed in women with a normal pregnancy and women experiencing SCH. Levels of arachidic acid, docosahexaenoic acid, and eicosenoic acid were significantly higher in the serum of women with SCH when compared to women with a normal pregnancy, in the second trimester. On the other hand, the levels of eicosadienoic acid and octadecanoic acid were significantly higher in SCH in the third trimester. Our findings demonstrate that serum fatty acid composition during the second and third trimesters was significantly associated with SCH in pregnant Chinese women.

Item Type: Article
Additional Information: Data availability: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request. Funding information: This work was supported by the National Natural Science Foundation of China (No.81571453, 81771607, 81871185, 81701477, 81961128004), The 111 Project (Yuwaizhuan (2016)32), The National Key Research and Development Program of Reproductive Health & Major Birth Defects Control and Prevention (2016YFC1000407), Chongqing Health Commission (2017ZDXM008, 2018ZDXM024), and Chongqing Science & Technology Commission (cstc2017jcyjBX0062). This study was also supported by the New Zealand Primary Growth Partnership post farm gate dairy programme, funded by Fonterra Co-operative Group Ltd, New Zealand and the New Zealand Ministry for Primary Industries.
Uncontrolled Keywords: general ,/dk/atira/pure/subjectarea/asjc/1000
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 20 Jun 2025 17:30
Last Modified: 23 Jun 2025 09:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/99659
DOI: 10.1038/s41598-020-63513-7

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