Tools
ToolsChen, Yu Ting, Zhang, Ting, Chen, Chang, Xia, Yin Yin, Han, Ting Li, Chen, Xu Yang, He, Xiao Ling, Xu, Ge, Zou, Zhen, Qi, Hong Bo, Zhang, Hua, Albert, Benjamin B., Colombo, John and Baker, Philip N. (2021) Associations of early pregnancy BMI with adverse pregnancy outcomes and infant neurocognitive development. Scientific Reports, 11. ISSN 2045-2322
Preview |
PDF (Associations of early pregnancy BMI with adverse pregnancy outcomes and infant neurocognitive development)
- Published Version
Available under License Creative Commons Attribution. Download (920kB) | Preview |
Abstract
The prevalence of overweight and obesity amongst reproductive women has been increasing worldwide. Our aim was to compare pregnancy outcomes and infant neurocognitive development by different BMI classifications and investigate whether early pregnancy BMI was associated with risks of adverse outcomes in a Southwest Chinese population. We analysed data from 1273 women enrolled in the Complex Lipids in Mothers and Babies (CLIMB) randomized controlled trial in Chongqing, China. Maternal BMI was classified as underweight, normal weight and overweight/obese according to the Chinese, WHO Asian, and WHO European standards. For the adverse pregnancy outcomes, after adjustment for potential confounders, an underweight BMI was associated with increased risk of small for gestational age (SGA) babies, and an overweight/obese BMI was associated with increased risk of maternal gestational diabetes mellitus (GDM), caesarean section (C-section), macrosomia and large for gestational age (LGA) babies. For infant neurocognitive development, 1017 mothers and their children participated; no significant differences were seen in the Mental Development Index (MDI) or the Psychomotor Development Index (PDI) between the three BMI groups. Our findings demonstrate that abnormal early pregnancy BMI were associated with increased risks of adverse pregnancy outcomes in Chinese women, while early pregnancy BMI had no significant influence on the infant neurocognitive development at 12 months of age.
| Item Type: | Article |
|---|---|
| Additional Information: | Data availability: The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request. Funding information: This study was supported by the New Zealand Primary Growth Partnership post farm gate dairy programme, funded by Fonterra Co-operative Group Ltd, New Zealand and the New Zealand Ministry for Primary Industries. This study was also supported by the fund from the Joint International Research Laboratory of Reproduction and Development, Institute of life sciences, Chongqing Medical University. |
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 20 Jun 2025 17:30 |
| Last Modified: | 23 Jun 2025 09:31 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/99657 |
| DOI: | 10.1038/s41598-021-83430-7 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |