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ToolsLuo, Xiaofang, Zou, Hong, Xu, Ping, Wen, Li, Stanley, Joanna L., Jiang, Xiaoxue, Han, Ting-li, Olson, David, Peng, Chuan, Zhang, Chen, Xiao, Xiaoqiu, Tong, Chao, Qi, Hongbo and Baker, Philip N. (2019) Blunted cardiac AMPK response is associated with susceptibility to ischemia/ reperfusion in Male offspring of gestational diabetic rats. Cellular Physiology and Biochemistry, 52 (5). pp. 1103-1116. ISSN 1015-8987
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Abstract
Background/Aims: Gestational diabetes mellitus (GDM) is closely associated with early perinatal complications and long-term health problems, such as cardiovascular disease, in offspring. AMP-activated protein kinase (AMPK) is cardioprotective, particularly in the treatment of ischemia/reperfusion (I/R). However, whether GDM programs offspring susceptibility to cardiac I/R and the involvement of AMPK remain unclear. Methods: Streptozotocin was administered to rats during mid pregnancy; the postpartum maternal metabolome was assessed by chromatography-mass spectrometry (GC-MS). Male offspring were subjected to body composition scanning followed by ex vivo global I/R. Cardiac signaling was determined by Western blotting. Results: The body weights (BWs) of the GDM male offspring were significantly heavier than those of the control group from the age of 8 weeks; the heart weights (HWs) and HW/BW were also increased in the GDM group compared to the control group. The ex vivo post-I/R cardiac contractile function recovery was significantly compromised in the GDM male offspring. The phosphorylation of AMPK and ACC was elevated by ex vivo I/R in both groups, but to a significantly lesser extent in the GDM group. Conclusion: GDM male offspring rats have higher risks of overgrowth and intolerance to cardiac I/R, which may be due to a compromised AMPK signaling pathway.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ampk,cardiac function,fetal programming,gestational diabetes mellitus,reperfusion,medicine(all),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 19 Jun 2025 15:30 |
| Last Modified: | 24 Jun 2025 13:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/99653 |
| DOI: | 10.33594/000000075 |
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