Indoline and tetrahydro-quinolines as prodrugs for tumour treatment

Searcey, Mark (2004) Indoline and tetrahydro-quinolines as prodrugs for tumour treatment. US2004157880A1.

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Abstract

Compounds of the general formula I or IA or a salt in which X is H, Y is a leaving group, R<1 >preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which X is joined, by cytochrome P450, in particular by CYP1B1, expressed at high levels in tumours. The prodrug is expected to be activated preferentially in tumour cells, where it will act as a DNA alkylating agent preventing cell division.

Item Type:	Patent
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Depositing User:	LivePure Connector
Date Deposited:	18 Jun 2025 15:30
Last Modified:	18 Jun 2025 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99641
DOI:	US2004157880A1

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