Analogues of the azinomycins as antitumour agents and as prodrugs

Searcey, Mark (2005) Analogues of the azinomycins as antitumour agents and as prodrugs. WO2006097730A1.

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Abstract

Compounds of general formula (I) or a salt thereof in which R1 is preferably an aromatic DNA binding subunit are oxidation-activated prodrugs. The compounds are expected to be converted into an epoxide at the alkene to which R2 is attached by cytochrome P450, in particular CYPIBI, expressed at high levels in tumours. R3 preferably comprises a Nitrogen mustard to provide a prodrug which has 2 alkylating groups. The prodrugs are expected to be activated preferentially in tumour cells.

Item Type:	Patent
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Depositing User:	LivePure Connector
Date Deposited:	18 Jun 2025 15:30
Last Modified:	18 Jun 2025 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99640
DOI:	WO2006097730A1

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