Kinetic and structural characterization of an intermediate in the biomineralization of bacterioferritin

Le Brun, Nick E., Wilson, Michael T., Andrews, Simon C., Guest, John R., Harrison, Pauline M., Thomson, Andrew J. and Moore, Geoffrey R. (1993) Kinetic and structural characterization of an intermediate in the biomineralization of bacterioferritin. FEBS Letters, 333 (1-2). pp. 197-202. ISSN 0014-5793

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Abstract

The mechanism by which iron-storage proteins take up and oxidise iron(II) is not understood. We show by rapid-kinetic and EPR measurements that iron uptake, in vitro, by a bacterial iron-storage protein, bacterioferritin, involves at least three kinetically distinguishable phases: phase 1, the binding of Fe(II) ions, probably at a dimeric iron ferroxidase centre; phase 2, oxidation of the Fe(II) dimer and production of mononuclear Fe(III); and phase 3, iron core formation.

Item Type:	Article
Uncontrolled Keywords:	bacterioferritin,iron(ii) dimer,iron-uptake,kinetic phase,biophysics,structural biology,biochemistry,molecular biology,genetics,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1304
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Chemistry of Life Processes
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	18 Jun 2025 09:30
Last Modified:	23 Jun 2025 10:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99616
DOI:	10.1016/0014-5793(93)80404-I

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