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ToolsZhang, Lan, Liu, Xiyao, Li, Junnan, Wang, Xing, Huang, Shuai, Luo, Xiaofang, Zhang, Hua, Wen, Li, Tong, Chao, Saffery, Richard, Yan, Jianying, Qi, Hongbo, Kilby, Mark D. and Baker, Philip N. (2020) Maternal utero-placental perfusion discordance in monochorionic-diamniotic twin pregnancies with selective growth restriction assessed by three-dimensional power Doppler ultrasound. Medical Science Monitor, 26. ISSN 1234-1010
Full text not available from this repository. (Request a copy)Abstract
Background: The aim of this study was to assess the correlation between selective growth restriction (sGR) and co-twin utero-placental perfusion discordance by using three-dimensional power Doppler (3DPD). Material/Methods: We prospectively recruited 60 sGR and 64 normal monochorionic-diamniotic (MCDA) twin pregnancies. Vascularization index (VI), flow index (FI), and vascularization flow index (VFI) were assessed by 3DPD, while umbilical artery pulsatility index (UA-PI), middle cerebral artery peak systolic velocity (MCA-PSV), pulsatility index (MCA-PI), and cerebroplacental ratio (CPR) were assessed by conventional Doppler imaging. Results: In sGR co-twins, the VI, FI, VFI, MCA-PI, and CPR were significantly lower, while the UA-PI and MCA-PSV were significantly greater, in the smaller fetuses compared with the larger fetuses; significant differences were also observed in the VI, FI, VFI, CPR, and UA-PI in normal co-twins. Compared with the appropriately grown twins, the discordances of the VI, FI, VFI, UA-PI, MCA-PI, and CPR were increased in the sGR cohort. The discordances of the VI, FI, VFI, UA-PI, MCA-PI, and CPR were associated with birthweight discordance, and the FI discordance and CPR discordance were independently associated with sGR. The combination of the FI and CPR discordance showed a higher predictive accuracy for sGR, with an area under the ROC curve of 0.813, and a sensitivity and specificity of 68.33% and 85.94%, respectively. Conclusions: MCDA twin pregnancies with birthweight discordance presented utero-placental perfusion deterioration assessed by 3DPD prior to sGR diagnosis. Co-twin utero-placental perfusion discordance was significantly correlated with growth discordance, and this correlation was more predictive of sGR when 3DPD was combined with conventional Doppler imaging.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | growth disorders,placental circulation,prenatal diagnosis,twins, monozygotic,ultrasonography, doppler, color,medicine(all) ,/dk/atira/pure/subjectarea/asjc/2700 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 11 Jun 2025 13:30 |
| Last Modified: | 24 Jun 2025 13:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/99468 |
| DOI: | 10.12659/MSM.919247 |
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