Metformin administration during pregnancy attenuated the long-term maternal metabolic and cognitive impairments in a mouse model of gestational diabetes

Zhao, Yalan, Zhou, Xiaobo, Zhao, Xue, Yu, Xinyang, Wang, Andi, Chen, Xuyang, Qi, Hongbo, Han, Ting Li, Zhang, Hua and Baker, Philip N. (2020) Metformin administration during pregnancy attenuated the long-term maternal metabolic and cognitive impairments in a mouse model of gestational diabetes. Aging, 12 (14). pp. 14019-14036. ISSN 1945-4589

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Abstract

Background: Gestational diabetes mellitus (GDM) is a metabolic disease that can have long-term adverse effects on the cognitive function of mothers. In our study, we explored the changes in metabolic health and cognitive function in mice of middle-and old-age after exposure to GDM, and whether metformin therapy during pregnancy provided long-term benefits. Results: Mice with GDM demonstrated significant cognitive impairment in old age, which was associated with insulin resistance. Gestational metformin therapy was shown to increase insulin sensitivity and improve cognition. The ovarian aging rate was also accelerated in mice exposed to GDM during pregnancy, which may be related to fatty acid metabolism in the ovaries. Conclusion: Treatment with metformin during pregnancy was shown to improve fatty acid metabolism in ovarian tissues. Method: During pregnancy, mice were fed with a high-fat diet (GDM group) or a low-fat diet (Control group), and a third group received metformin while receiving a high-fat diet (Treatment group). At 12 months old, the mice completed an oral glucose tolerance test, insulin tolerance test, Morris water maze test, female sex hormones were measured, and metabolite profiles of tissue from the ovaries, hypothalamus, and pituitary glands were analysed using gas chromatography-mass spectrometry.

Item Type:	Article
Uncontrolled Keywords:	cognitive impairment,gestational diabetes,hpo-axis,insulin resistance,metformin,ageing,cell biology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1302
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	10 Jun 2025 16:30
Last Modified:	23 Jun 2025 09:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99438
DOI:	10.18632/aging.103505

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