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ToolsLi, Xin, Yu, Jiaxiao, Li, Qingshu, Yan, Jianying, Tian, Jing, Tong, Chao, Tong, Qi, Qi, Hongbo, Saffery, Richard, Kilby, Mark D. and Baker, Philip N. (2021) Vitamin D status in women with dichorionic twin pregnancies and their neonates: A pilot study in China. BMC Pregnancy and Childbirth, 21. ISSN 1471-2393
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Abstract
Background: Vitamin D deficiency is a global public health issue in women and children and is associated with adverse impacts on child growth, such as rickets. However, prior studies have mainly focused on measuring vitamin D levels in singleton pregnant women and their offspring, and very limited studies have revealed the prevalence of vitamin D deficiency in twin pregnant women and their offspring. The aim of this study was to investigate vitamin D levels in twin-pregnant women and their neonates. We also explored the correlation of maternal vitamin D levels with neonatal outcomes and infant growth. Methods: A prospective subcohort investigation was carried out among 72 dichorionic, diamniotic twin-pregnant mothers and their twin offspring from the Longitudinal Twin Study. Peripheral blood was collected from the mothers in the third trimester, and cord blood was collected from neonates at birth to identify 25[OH]D levels. Data on the characteristics of the mothers and neonates were collected. Infant growth data and food sensitivities were also collected. Results: The average maternal 25[OH]D level was 31.78 ng/mL, with 19.4% being deficient and 20.8% insufficient, while the average neonatal 25[OH]D level was 15.37 ng/mL, with 99.3% being deficiency or insufficient. A positive correlation was found between maternal and neonatal 25[OH]D levels (beta-value: 0.43, 95% CI: 0.37, 0.49). Interestingly, the higher the maternal 25[OH]D level was, the smaller the cotwin birthweight discordance (beta-value: -2.67, 95% CI: − 5.11, − 0.23). In addition, the infants of mothers with vitamin D deficiency were more likely to be allergic to foods at 6 months than those of mothers with vitamin D sufficiency. Conclusions: Twin neonates were at high risk of vitamin D deficiency, although their mothers’ vitamin D deficiency partially improved. Higher maternal vitamin D levels were associated with smaller discordance of cotwin birthweight. Trial registration: Chinese Clinical Trial Registry ChiCTR-OOC-16008203, 1st April 2016.
| Item Type: | Article |
|---|---|
| Additional Information: | Availability of data and materials: The LoTiS is being conducted mainly at the First Affiliated Hospital of Chongqing Medical University and Chongqing Women and Children’s Health Center, where the staff are responsible for the collection, management, and distribution of data. All data are stored electronically in an anonymous format and are currently only available to LoTiS researchers. The datasets used and/or analyzed during the current study are available from the corresponding author upon request (chaotongcqmu@163.com). |
| Uncontrolled Keywords: | neonates,nutrition,prospective study,twin pregnancies,vitamin d,obstetrics and gynaecology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2729 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 28 May 2025 10:30 |
| Last Modified: | 03 Jun 2025 10:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/99329 |
| DOI: | 10.1186/s12884-021-03707-7 |
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