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ToolsHe, Xiao-ling, Hu, Xiao-jing, Luo, Bai-yu, Xia, Yin-Yin, Zhang, Ting, Saffery, Richard, De Seymour, Jamie, Zou, Zhen, Xu, Ge, Zhao, Xue, Qi, Hong-bo, Han, Ting-Li, Zhang, Hua and Baker, Philip N. (2022) The effects of gestational diabetes mellitus with maternal age between 35 and 40 years on the metabolite profiles of plasma and urine. BMC Pregnancy and Childbirth, 22. ISSN 1471-2393
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Abstract
Background: Gestational diabetes mellitus (GDM) is defined as impaired glucose tolerance in pregnancy and without a history of diabetes mellitus. While there are limited metabolomic studies involving advanced maternal age in China, we aim to investigate the metabolomic profiling of plasma and urine in pregnancies complicated with GDM aged at 35–40 years at early and late gestation. Methods: Twenty normal and 20 GDM pregnant participants (≥ 35 years old) were enlisted from the Complex Lipids in Mothers and Babies (CLIMB) study. Maternal plasma and urine collected at the first and third trimester were detected using gas chromatography-mass spectrometry (GC-MS). Results: One hundred sixty-five metabolites and 192 metabolites were found in plasma and urine respectively. Urine metabolomic profiles were incapable to distinguish GDM from controls, in comparison, there were 14 and 39 significantly different plasma metabolites between the two groups in first and third trimester respectively. Especially, by integrating seven metabolites including cysteine, malonic acid, alanine, 11,14-eicosadienoic acid, stearic acid, arachidic acid, and 2-methyloctadecanoic acid using multivariant receiver operating characteristic models, we were capable of discriminating GDM from normal pregnancies with an area under curve of 0.928 at first trimester. Conclusion: This study explores metabolomic profiles between GDM and normal pregnancies at the age of 35–40 years longitudinally. Several compounds have the potential to be biomarkers to predict GDM with advanced maternal age. Moreover, the discordant metabolome profiles between the two groups could be useful to understand the etiology of GDM with advanced maternal age.
| Item Type: | Article |
|---|---|
| Additional Information: | Availability of data and materials: The datasets generated during this study are available from the corresponding author on reasonable request. Funding information: This research was sponsored by the National Natural Science Foundation of China (grant numbers 81971406, 81771607, 81871185), The 111 Project (Yuwaizhuan (2016)32), The National Key Research and Development Program of Reproductive Health & Major Birth Defects Control and Prevention (2016YFC1000407), Chongqing Municipal Education Commission(KJZD-K202100407), Chongqing Science & Technology Commission(cstc2021jcyj-msxmX0213), the Joint International Research Laboratory of Reproduction and Development, Institute of life sciences, Chongqing Medical University. |
| Uncontrolled Keywords: | advanced maternal age,gestational diabetes mellitus,metabolomics,pregnancy,obstetrics and gynaecology ,/dk/atira/pure/subjectarea/asjc/2700/2729 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 07 May 2025 16:30 |
| Last Modified: | 09 May 2025 09:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/99204 |
| DOI: | 10.1186/s12884-022-04416-5 |
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