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ToolsChen, Jie, Sun, Yuhao, Dan, Lintao, Wellens, Judith, Yuan, Shuai, Yang, Hong, Tong, Tammy Y. N., Cross, Amanda J., Papadimitriou, Nikos, Meyer, Antoine, Dahm, Christina C., Larsson, Susanna C., Wolk, Alicja, Ludvigsson, Jonas F., Tsilidis, Kostas, Giovannucci, Edward, Satsangi, Jack, Wang, Xiaoyan, Theodoratou, Evropi, Chan, Simon S. M. and Li, Xue and on behalf of the EPIC Investigators (2025) Composition of plant-based diets and the incidence and prognosis of inflammatory bowel disease: A multinational retrospective cohort study. The Lancet Regional Health - Europe, 52. ISSN 2666-7762
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Abstract
Background: Many currently proposed diets for inflammatory bowel disease (IBD) focus on increasing plant-based foods, although a vegetarian diet can still contain products such as emulsifiers and refined grains that are believed to negatively impact IBD incidence and progression. To better inform dietary management in IBD, we investigated the association between plant-based diets and the incidence and complications of IBD. Methods: We leveraged data from the UK Biobank (UKB, 2009–2022) including 187,888 participants free of IBD at baseline and the European Prospective Investigation into Cancer and Nutrition (EPIC, 1991–2010) cohort including 341,539 individuals free of IBD across centres among Denmark, France, Germany, Greece, Italy, the Netherlands, Sweden and UK. Healthy and unhealthy diets were characterised using plant-based diet indexes (PDIs); in individual participants, these were based on the 24-h dietary recalls for UKB and food frequency questionnaires for EPIC. The primary outcome was the incidence of IBD; secondary outcomes evaluated endpoints of disease prognosis (IBD-related surgery, diabetes, cardiovascular diease, and all-cause mortality). Cox regression was applied to estimate hazard ratios (HRs). Findings: In the UKB (925 incident IBD, median follow-up 11.6 years, IQR 1.3 years), higher adherence to healthy PDI was associated with a lower IBD risk (HR 0.75, 95% CI 0.60–0.94), while higher alignment to an unhealthy PDI associated with an increased risk (HR 1.48, 95% CI 1.21–1.82) when comparing extreme quintiles of PDIs. Among individuals with established IBD, healthy PDI was inversely associated (HR 0.50, 95% CI 0.30–0.83) and unhealthy PDI was positively associated (HR 2.12, 95% CI 1.30–3.44) with need for IBD-related surgery. We did not observe significant associations between PDIs and risk of cardiovascular disease, diabetes mellitus or mortality. In the EPIC study (548 incident IBD, median follow-up 14.5 years, IQR 7.0 years), the HR of incident IBD for healthy PDI was 0.71 (95% CI 0.59–0.85) and for unhealthy PDI was 1.54 (95% CI 1.30–1.84). Interpretation: We provide evidence that the composition of a plant-based diet may be an important determinant of the risk of developing IBD, and of disease course after diagnosis. Further research is needed to explore the mechanistic pathways linking plant-based diets and IBD incidence and prognosis. Funding: National Natural Science Foundation of China, Natural Science Fund for Distinguished Young Scholars of Zhejiang Province, National Undergraduate Training Program for Innovation and Entrepreneurship, CRUK Career Development Fellowship, The “Co-PI” project, Natural Science Fund for Excellent Young Scholars of Hunan Province.
| Item Type: | Article |
|---|---|
| Additional Information: | Data sharing statement: The datasets analysed during the current study are available in public, open access repository (https://www.ukbiobank.ac.uk/and https://epic.iarc.fr/). |
| Uncontrolled Keywords: | genetic susceptibility,incidence,inflammatory bowel disease,mediation analysis,plant-based diet,prognosis,internal medicine,oncology,health policy,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2724 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 May 2025 11:30 |
| Last Modified: | 09 May 2025 09:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/99184 |
| DOI: | 10.1016/j.lanepe.2025.101264 |
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