Diffuse large B-cell lymphoma-leg type masquerading as venous eczema

Moolchandani, Harsha, Liu, Bo, Cunningham, Joel, Staniforth, Joy, Marriott, Ben and Yaakub, Azaharry (2025) Diffuse large B-cell lymphoma-leg type masquerading as venous eczema. JAAD Case Reports, 56. pp. 80-82. ISSN 2352-5126

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Abstract

Primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT), is a rare high-grade form of primary cutaneous lymphoma. It often presents as red to violaceous nodules or plaques on lower limbs. We report a case of PCDLBCL-LT presenting initially as cellulitis. The skin changes did not respond to oral and intravenous antibiotics and management for venous eczema was subsequently commenced. The patient then developed 2 large deep subcutaneous masses and core biopsy confirmed a diagnosis of a mature high-grade B-cell lymphoma. Review of the patient’s history revealed a prior diagnosis of high-grade B-cell lymphoma 22 years previously. This case demonstrates that PCDLBCL-LT can present with clinical signs in keeping with a diagnosis of cellulitis or venous eczema. In the context of progressive nodular skin changes biopsy should always be considered, particularly when the patient has a prior history of a hematologic malignancy.

Item Type:	Article
Uncontrolled Keywords:	cellulitis,chronic venous insufficiency,cutaneous b-cell lymphoma,histopathology,immunohistochemistry,localized radiotherapy,venous eczema,dermatology ,/dk/atira/pure/subjectarea/asjc/2700/2708
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	24 Apr 2025 10:30
Last Modified:	27 Apr 2025 06:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99079
DOI:	10.1016/j.jdcr.2024.11.028

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