A 14-year study of serum glial fibrillary acidic protein and total tau in premanifest Huntington's

Owen, Natalia E., Voysey, Zanna J., Holbrook, Jonathan A., Malpetti, Maura, Le Draoulec, Clara, Spindler, Lennart R. B., Goodman, Anna O. G., Lazar, Alpar S. and Barker, Roger A. (2025) A 14-year study of serum glial fibrillary acidic protein and total tau in premanifest Huntington's. Annals of Clinical and Translational Neurology. ISSN 2328-9503

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Abstract

There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, finding that NfL demonstrates high prognostic value and distinct longitudinal dynamics in premanifest/transitional HD. Here, we report the corresponding results for serum glial fibrillary acidic protein and total tau, providing the first longitudinal and head-to-head study of these biomarkers in HD. Our findings do not support the utility of these analytes as prognostic biomarkers in premanifest and transitional HD.

Item Type:	Article
Additional Information:	Data Availability Statement: The data that support the findings of this study are available upon request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Funding: This work was supported by Centre Parkinson Plus Grant and Cure Parkinson's Trust; Association of British Neurologists/Guarantors of Brain, Clinical Research Fellowship; Wellcome Trust (203151/A/16/Z, 203151/Z/16/Z); NIHR Cambridge Biomedical Research Centre (BRC-1215-20014); UKRI Medical Research Council (MC_PC_17230); Alzheimer's Research UK (ARUK-RADF2021A-010); UK Medical Research Council.
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Related URLs:	https://onlinelibrary.wiley.com/doi/10.1...
Depositing User:	LivePure Connector
Date Deposited:	23 Apr 2025 14:30
Last Modified:	23 Apr 2025 14:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99056
DOI:	10.1002/acn3.70057

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