Footprints in the Sno: Investigating the cellular and molecular mechanisms of SNORD116

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Holmes, Terri L., Chabronova, Alzbeta, Denning, Chris, James, Victoria, Peffers, Mandy J. and Smith, James G. W. (2025) Footprints in the Sno: Investigating the cellular and molecular mechanisms of SNORD116. Open Biology, 15 (3). ISSN 2046-2441

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Abstract

The small nucleolar RNA (snoRNA) SNORD116 is a small non-coding RNA of interest across multiple biomedical fields of research. Much of the investigation into SNORD116 has been undertaken in the context of the congenital disease Prader-Willi syndrome, wherein SNORD116 expression is lost. However, emerging evidence indicates wider roles in various disease and tissue contexts such as cellular growth, metabolism and signalling. Nevertheless, a conclusive mechanism of action for SNORD116 remains to be established. Here, we review the key findings from these investigations, with the aim of identifying common elements from which to elucidate potential targets and mechanisms of SNORD116. A key recurring element identified is disruption to the insulin/IGF-1 and PI3K/mTOR signalling pathways, contributing to many of the phenotypes associated with SNORD116 modulation explored in this review.

Item Type:	Article
Additional Information:	Data accessibility: All DNA sequences were obtained from the Ensembl database; reference codes are provided in table 1. Funding information: Funding was received from the British Heart Foundation (SP/F/22/150044,582 CRMR/21/290009, and PG/21/10545) and Animal Free Research UK (AFR19-20293).
Uncontrolled Keywords:	cell signalling,metabolism,prader-willi syndrome,snord116,snorna,neuroscience(all),immunology,biochemistry, genetics and molecular biology(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	01 Apr 2025 09:30
Last Modified:	24 Apr 2025 13:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98916
DOI:	10.1098/rsob.240371

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