Cortistatin and plakinamine steroidal alkaloids from the marine sponges of the genus Corticium: Insights into their chemistry, pharmacology, pharmacokinetics and structure activity relationships (SARs)

Tammam, Mohamed A., Aouidate, Adnane, Mahmoud, Manar M., Gamal El-Din, Mariam I. and El-Demerdash, Amr (2025) Cortistatin and plakinamine steroidal alkaloids from the marine sponges of the genus Corticium: Insights into their chemistry, pharmacology, pharmacokinetics and structure activity relationships (SARs). RSC Advances, 15 (12). pp. 9092-9107. ISSN 2046-2069

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Abstract

Cortistatins and plakinamines represent a unique class of marine-derived steroidal alkaloids, renowned for their structural diversity and potent pharmacological activities. This review provides a comprehensive overview of their chemical characteristics, pharmacological profiles, pharmacokinetics, and drug-likeness properties, with a particular focus on structure–activity relationships (SARs). Indeed, we explored their distinct molecular architectures and classification within the broader family of marine alkaloids, highlighting key subclasses and derivatives identified through advanced analytical techniques. Their broad-spectrum bioactivities, including anticancer, anti-inflammatory, antimicrobial, and antiviral effects, are discussed in detail, supported by insights into SARs and pharmacophore identification that illuminate the molecular basis of their bioactivity. Additionally, we evaluate their pharmacokinetic attributes, including absorption, distribution, metabolism, and elimination (ADME), alongside their compliance with drug-likeness criteria, offering a holistic perspective on their potential for drug development.

Item Type:	Article
Additional Information:	Data availability statement: This is a review article, and no new data were generated or analyzed in this study. All data discussed are based on published literature cited within the manuscript.
Uncontrolled Keywords:	sdg 14 - life below water ,/dk/atira/pure/sustainabledevelopmentgoals/life_below_water
Faculty \ School:	Faculty of Science > School of Chemistry, Pharmacy and Pharmacology
Depositing User:	LivePure Connector
Date Deposited:	26 Mar 2025 10:30
Last Modified:	01 Apr 2025 14:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98885
DOI:	10.1039/D4RA08718F

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