A roadmap towards standardized neuroimaging approaches for human thalamic nuclei

Segobin, Shailendra, Haast, Roy A. M., Kumar, Vinod Jangir, Lella, Annalisa, Alkemade, Anneke, Bach Cuadra, Meritxell, Barbeau, Emmanuel J., Felician, Olivier, Pergola, Giulio, Pitel, Anne Lise, Saranathan, Manojkumar, Tourdias, Thomas and Hornberger, Michael (2024) A roadmap towards standardized neuroimaging approaches for human thalamic nuclei. Nature Reviews Neuroscience, 25 (12). pp. 792-808. ISSN 1471-003X

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Abstract

The thalamus has a key role in mediating cortical–subcortical interactions but is often neglected in neuroimaging studies, which mostly focus on changes in cortical structure and activity. One of the main reasons for the thalamus being overlooked is that the delineation of individual thalamic nuclei via neuroimaging remains controversial. Indeed, neuroimaging atlases vary substantially regarding which thalamic nuclei are included and how their delineations were established. Here, we review current and emerging methods for thalamic nuclei segmentation in neuroimaging data and consider the limitations of existing techniques in terms of their research and clinical applicability. We address these challenges by proposing a roadmap to improve thalamic nuclei segmentation in human neuroimaging and, in turn, harmonize research approaches and advance clinical applications. We believe that a collective effort is required to achieve this. We hope that this will ultimately lead to the thalamic nuclei being regarded as key brain regions in their own right and not (as often currently assumed) as simply a gateway between cortical and subcortical regions.

Item Type:	Article
Uncontrolled Keywords:	neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Groups > Mental Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	20 Mar 2025 15:30
Last Modified:	28 Mar 2025 13:15
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98856
DOI:	10.1038/s41583-024-00867-1

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