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ToolsZhai, Keran, Rhodes, Jack and Zipfel, Cyril (2024) A peptide-receptor module links cell wall integrity sensing to pattern-triggered immunity. Nature Plants, 10 (12). pp. 2027-2037. ISSN 2055-026X
Full text not available from this repository. (Request a copy)Abstract
Plants employ cell-surface receptors to perceive non- or altered-self, including the integrity of their cell wall. Here we identify a specific ligand–receptor module responsive to cell wall damage that potentiates immunity in Arabidopsis. Disruption of cell wall integrity by inhibition of cellulose biosynthesis promotes pattern-triggered immunity transcriptionally in a manner dependent on the receptor kinase MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2 (MIK2). Notably, while MIK2 can perceive peptides of the large SERINE RICH ENDOGENOUS PEPTIDE family, a single member of this family, SCOOP18, is transcriptionally induced upon cell wall damage and is required for subsequent responses such as lignification and immunity potentiation. Collectively, our results identify the SCOOP18–MIK2 ligand–receptor module as an important central hub, connecting plant cell wall integrity sensing with immunity.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This work was supported by the University of Zurich (C.Z.), the Gatsby Charitable Foundation (C.Z.), the European Research Council under the European Union's Horizon 2020 research and innovation programme no. 773153 (project IMMUNO-PEPTALK) (C.Z.) and the Swiss National Science Foundation grant nos. 31003A_182625, 310030_212382 and 320030_228294 (C.Z.). |
| Uncontrolled Keywords: | plant science ,/dk/atira/pure/subjectarea/asjc/1100/1110 |
| Faculty \ School: | Faculty of Science > The Sainsbury Laboratory |
| UEA Research Groups: | Faculty of Science > Research Groups > Plant Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 20 Mar 2025 15:30 |
| Last Modified: | 28 Mar 2025 13:10 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98836 |
| DOI: | 10.1038/s41477-024-01840-7 |
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