Tools
ToolsVenables, Zoe Claire, Tokez, Selin, Hollestein, Loes M., Mooyaart, Antien L., van den Bos, Renate Ruth, Rous, Brian, Leigh, Irene M., Nijsten, Tamar and Wakkee, Marlies (2022) Validation of four cutaneous squamous cell carcinoma staging systems using nationwide data. British Journal of Dermatology, 186 (5). pp. 835-842. ISSN 0007-0963
Preview |
PDF (bjd0835)
- Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (479kB) | Preview |
Abstract
Background: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer worldwide with relatively low metastatic potential (2–5%). Developments in therapeutic options have highlighted the need to better identify high-risk patients who could benefit from closer surveillance, adjuvant therapies and baseline/follow-up imaging, while at the same time safely omitting low-risk patients from further follow-up. Controversy remains regarding the predictive performance of current cSCC staging systems and which methodology to adopt. Objectives: To validate the performance of four cSCC staging systems [American Joint Committee on Cancer 8th edition (AJCC8), Brigham and Women’s Hospital (BWH), Tübingen and Salamanca T3 refinement] in predicting metastasis using a nationwide cohort. Methods: A nested case–control study using data from the National Disease Registration Service, England, 2013–2015 was conducted. Metastatic cSCC cases were identified using an algorithm to identify all potential cases for manual review. These were 1 : 1 matched on follow-up time to nonmetastatic controls randomly selected from 2013. Staging systems were analysed for distinctiveness, homogeneity, monotonicity, specificity, positive predictive value (PPV), negative predictive value (NPV) and c-index. Results: We included 887 metastatic cSCC cases and 887 nonmetastatic cSCC controls. The BWH system showed the highest specificity [92.8%, 95% confidence interval (CI) 90.8–94.3%, PPV (13.2%, 95% CI 10.6–16.2) and c-index (0.84, 95% CI 0.82–0.86). The AJCC8 showed superior NPV (99.2%, 95% CI 99.2–99.3), homogeneity and monotonicity compared with the BWH and Tübingen diameter and thickness classifications (P < 0.001). Salamanca refinement did not show any improvement in AJCC8 T3 cSCC staging. Conclusions: We validated four cSCC staging systems using the largest nationwide dataset of metastatic cSCC so far. Although the BWH system showed the highest overall discriminative ability, PPV was low for all staging systems, which shows the need for further improvement and refining of current cSCC staging systems.
| Item Type: | Article |
|---|---|
| Additional Information: | This work uses data that have been provided by patients and collected by the National Health Service as part of their care and support. The data are collated, maintained and quality assured by the National Disease Registration Service, which is part of Public Health England. |
| Uncontrolled Keywords: | dermatology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2708 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 20 Mar 2025 11:30 |
| Last Modified: | 28 Mar 2025 13:15 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98821 |
| DOI: | 10.1111/bjd.20909 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |