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ToolsTokez, Selin, Wakkee, Marlies, Kan, Wilner, Venables, Zoe C., Mooyaart, Antien L., Louwman, Marieke, Nijsten, Tamar and Hollestein, Loes M. (2022) Cumulative incidence and disease-specific survival of metastatic cutaneous squamous cell carcinoma: A nationwide cancer registry study. Journal of the American Academy of Dermatology, 86 (2). pp. 331-338. ISSN 0190-9622
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Abstract
Background: Cutaneous squamous cell carcinoma (cSCC) represents the most serious form of keratinocyte cancers because of its metastatic potential. Studies on nationwide incidence and disease-specific survival rates of metastatic cSCC (mcSCC) are lacking. Objective: To investigate the cumulative incidence and disease-specific survival of patients with mcSCC in the Dutch population and assess patient-based risk factors. Methods: We conducted a nationwide cancer registry study including all patients with the first cSCC in 2007 or 2008, using data from the Netherlands Cancer Registry, the nationwide network and registry of histopathology and cytopathology, and Statistics Netherlands. Cumulative incidence and Kaplan-Meier curves were calculated, and time-dependent Cox proportional hazards regression analyses were used. Results: Of the 11,137 patients, metastases developed in 1.9% (n = 217). The median time to metastasis was 1.5 years (interquartile range 0.6-3.8 years). The risk factors were age (adjusted hazard ratio [aHR] 1.03, 95% CI 1.02-1.05), male sex (aHR 1.7, 95% CI 1.3-2.3), and immunosuppression (aHR [organ transplant recipient] 5.0, 95% CI 2.5-10.0; aHR [hematologic malignancy] 2.7, 95% CI 1.6-4.6). The 5-year disease-specific survival for patients with mcSCC was 79.1%. Limitations: Only histopathologically confirmed mcSCCs were included. Conclusion: About 2% of cSCCs metastasize, with higher risk for men, increasing age, and immunocompromised patients. Disease-specific survival for patients with mcSCC is high.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding sources: This work was supported by Sanofi Genzyme (grant number SGZ-2018-12154 ). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or the writing of the report. |
| Uncontrolled Keywords: | cancer registry,cutaneous squamous cell carcinoma,epidemiology,hematologic malignancy,incidence,keratinocyte carcinoma,metastasis,organ transplantation,survival,dermatology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2708 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 19 Mar 2025 14:30 |
| Last Modified: | 28 Mar 2025 13:15 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98809 |
| DOI: | 10.1016/j.jaad.2021.09.067 |
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