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ToolsScott, Jamie, Yates, Max, Tanaka, Toshiko, Ferrucci, Luigi, Cameron, Donnie and Welch, Ailsa A. (2025) Cross-sectional associations between clinical biochemistry and nutritional biomarkers and sarcopenic indices of skeletal muscle in the Baltimore Longitudinal Study of Aging. The Journal of Nutrition, 155 (5). pp. 1535-1548. ISSN 0022-3166
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Abstract
Background: Investigating relationships between nutritional and clinical biochemistry biomarkers and skeletal muscle mass, strength and function (sarcopenic indices) may 1) highlight micronutrients of interest for potential preventive or treatment strategies for sarcopenia, or 2) highlight biomarkers that may be useful for identifying individuals at risk of sarcopenia. Objectives: Investigate associations between nutritional biomarkers (vitamin D, vitamin B 12, folate, magnesium, potassium, calcium, and iron), clinical biomarkers (hemoglobin, ferritin, albumin, creatinine, and hemoglobin A1c: HbA1c), and sarcopenic indices (appendicular lean mass: ALM); height-adjusted ALM: ALM ht; fat-free mass as a percentage of total body weight; extended short physical performance battery score: extSPPB; height-adjusted hand grip strength: HGS ht; height-adjusted knee extension concentric strength, and; height-adjusted knee extension isometric strength) in males and females. Methods: Using multivariable linear regression analysis, we investigated cross-sectional associations between biomarkers and sarcopenic indices in data collected from 1761 participants (age 22–103 y) from the Baltimore Longitudinal Study of Aging. Results: Hemoglobin was positively associated with ALM (β = 0.20, P = 0.021), HGS ht (β = 0.25, P = 0.001), and extSPPB (β = 0.13, P = 0.024) in males, and with extSPPB in females (β = 0.15, P = 0.019). In males, serum iron was positively associated with ALM ht (β = 0.0021, P = 0.038) and extSPPB (β = 0.0043, P = 0.045). In females, ferritin was positively associated with knee-extension strength measurements. Serum creatinine was positively associated with lean mass measures in males and females and with muscle strength and function measures in males with normal renal function (estimated glomerular filtration rate ≥60 mL/min/1.73 m 2). In males, high HbA1c was associated with lower ALM ht (β = –0.21, P = 0.023), extSPPB (β = –0.40, P = 0.027), and HGS ht (β = –0.56, P = 0.031). In males and females, magnesium was positively associated with extSPPB, and potassium was positively associated with measures of knee-extension strength. Conclusions: The associations found between measures of iron status and creatinine and sarcopenic indices, in males in particular, indicate potential importance for muscle health. Future longitudinal and intervention studies are warranted to confirm these findings.
| Item Type: | Article |
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| Additional Information: | Data Availability Statement: The raw data supporting the conclusion of this manuscript will be made available without undue reservation, by the authors, to any qualified researcher, provided that they submit a research proposal on the Baltimore Longitudinal Study of Aging website: https://www.blsa.nih.gov/how-apply. Funding Information: This work was supported by the Wellcome Trust EDESIA PhD Programme (218467/Z/19/Z). The funders had no role in the study design, data collection, data analysis, decision to publish or preparation of the manuscript. |
| Uncontrolled Keywords: | aging,clinical biochemistry,grip strength,muscle mass,muscle strength,nutrition,nutritional biomarkers,physical performance,sarcopenia,skeletal muscle,nutrition and dietetics,medicine (miscellaneous) ,/dk/atira/pure/subjectarea/asjc/2900/2916 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health |
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| Depositing User: | LivePure Connector |
| Date Deposited: | 18 Mar 2025 10:30 |
| Last Modified: | 06 May 2025 10:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98777 |
| DOI: | 10.1016/j.tjnut.2025.03.006 |
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