The relationship between exhaled volatile organic compounds and lung function change in idiopathic pulmonary fibrosis

Hayton, Conal, Ahmed, Waqar M., Terrington, Dayle, White, Iain R., Chaudhuri, Nazia, Leonard, Colm, Wilson, Andrew M. and Fowler, Stephen J. (2025) The relationship between exhaled volatile organic compounds and lung function change in idiopathic pulmonary fibrosis. Thorax. ISSN 0040-6376

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Abstract

Volatile organic compounds (VOCs) in exhaled breath have shown promise as biomarkers in idiopathic pulmonary fibrosis (IPF). We analysed breath from 57 people with IPF using thermal desorption–gas chromatography–mass spectrometry to identify VOCs related to lung function change over 12 months. A LASSO regression model selected 63 VOCs associated with relative change in forced vital capacity (8 with correlation coefficient (CC) ≥0.20 on Spearman’s rank analysis), and 28 associated with relative change in diffusion capacity of the lung for carbon monoxide % predicted (12 with CC ≥0.20). Secondary analyses demonstrated a correlation between VOCs and baseline lung function parameters and association with survival. This study suggests that there may be a volatile signature of prognosis in IPF that merits further validation.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Respiratory and Airways Group Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	LivePure Connector
Date Deposited:	17 Mar 2025 14:30
Last Modified:	14 May 2025 00:10
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98765
DOI:	10.1136/thorax-2024-222321

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