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ToolsChandran, Aneesh, Rosenheim, Joshua, Nageswaran, Gayathri, Swadling, Leo, Pollara, Gabriele, Gupta, Rishi K., Burton, Alice R., Guerra-Assunção, José Afonso, Woolston, Annemarie, Ronel, Tahel, Pade, Corinna, Gibbons, Joseph M., Sanz-Magallon Duque De Estrada, Blanca, Robert de Massy, Marc, Whelan, Matthew, Semper, Amanda, Brooks, Tim, Altmann, Daniel M., Boyton, Rosemary J., McKnight, Áine, Captur, Gabriella, Manisty, Charlotte, Treibel, Thomas Alexander, Moon, James C., Tomlinson, Gillian S., Maini, Mala K., Chain, Benjamin M., Noursadeghi, Mahdad and Hickling, Lauren M. and COVIDsortium Investigators (2022) Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections. Cell Reports Medicine, 3 (3). ISSN 2666-3791
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Abstract
Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates of protective immunity to future variants, but we lack insights into immune responses before or at the time virus is first detected. We use blood transcriptomics, multiparameter flow cytometry, and T cell receptor (TCR) sequencing spanning the time of incident non-severe infection in unvaccinated virus-naive individuals to identify rapid type 1 interferon (IFN) responses common to other acute respiratory viruses and cell proliferation responses that discriminate SARS-CoV-2 from other viruses. These peak by the time the virus is first detected and sometimes precede virus detection. Cell proliferation is most evident in CD8 T cells and associated with specific expansion of SARS-CoV-2-reactive TCRs, in contrast to virus-specific antibodies, which lag by 1–2 weeks. Our data support a protective role for early type 1 IFN and CD8 T cell responses, with implications for development of universal T cell vaccines.
| Item Type: | Article |
|---|---|
| Additional Information: | Data and code availability: •Open access to new transcriptional profiling data and essential anonymised metadata is available online through ArrayExpress: E-MTAB-10022 and ArrayExpress: E-MTAB-11345. TCR sequencing data are available at NCBI Short Read Archive: SUB9362448. Requests for access to individual de-identified participant level data will be considered (subject to a data transfer agreement) by an access committee via an online application (https://covid-consortium.com/application-for-samples/), on the basis of availability and scientific merit within the scope of research ethics approvals, participant consent, and data governance. Responses to applications will be made within 4 weeks. •No custom code was generated for the present analysis. •Any additional information required to reanalyze the data reported in this work paper is available from the Lead contact upon request. |
| Uncontrolled Keywords: | cd8 t cells,non-severe sars-cov-2 infection,type 1 interferon,biochemistry, genetics and molecular biology(all),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 04 Mar 2025 17:30 |
| Last Modified: | 28 Mar 2025 13:14 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98671 |
| DOI: | 10.1016/j.xcrm.2022.100557 |
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