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ToolsLofthouse, Katie, Davies, Alana, Hodgekins, Joanne and Meiser-Stedman, Richard (2025) Systematic review and meta-analysis: Imputing response rates for first-line psychological treatments for posttraumatic stress disorder in youth. Journal of the American Academy of Child and Adolescent Psychiatry. ISSN 0890-8567
Full text not available from this repository. (Request a copy)Abstract
Objective: Meta-analyses assessing psychological therapies for posttraumatic stress disorder (PTSD) in youth have demonstrated their effectiveness using standardized mean differences. Imputation of response rates (ie, 50% or greater reduction in symptoms) may facilitate easier interpretation for clinicians. Method: We searched 4 databases (MEDLINE, PsycINFO, PTSDPubs, and Web of Science) and screened 1,654 records to include 60 randomized controlled trials (52 trauma-focused cognitive–behavioral therapy [TF-CBT], 8 eye movement desensitization [EMDR]) with a total of 5,113 participants, comparing psychological therapies for PTSD against control conditions in youth. Data from randomized controlled trials of EMDR and TF-CBT for PTSD were used to impute response rates, establishing how many patients display 50% reduction, 20% reduction, and reliable improvement and deterioration (using reliable change indices) in PTSD and depression. Results: The proportion of youth exhibiting a 50% reduction in PTSD symptoms was 0.48 (95% CI = 0.41-0.55) for TF-CBT, 0.30 (0.24-0.37) for EMDR, and 0.46 (0.39-0.52) for all psychological therapies, compared to 0.20 (0.16-0.24) for youth in control conditions. Reliable improvement was displayed by 0.53 (0.45-0.61; TF-CBT 0.55 [0.46-0.64], EMDR 0.42[0.30-0.55]) of youth receiving psychological therapies, compared to 0.25 (0.20-0.30) of youth in control conditions. Reliable deterioration was seen in 0.01 (0.01-0.02) of youth receiving psychological therapies, compared to 0.13 (0.08-0.20) of youth in control conditions. There was a high degree of heterogeneity in the included studies. Conclusion: Psychological therapies, in particular TF-CBT, for young people with PTSD are effective and unlikely to cause deterioration, with around half of youth receiving TF-CBT exhibiting 50% symptom reduction.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ptsd,meta-analysis,review,therapy,youth,psychiatry and mental health,developmental and educational psychology ,/dk/atira/pure/subjectarea/asjc/2700/2738 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Groups > Mental Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 03 Mar 2025 16:30 |
| Last Modified: | 27 May 2025 11:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98641 |
| DOI: | 10.1016/j.jaac.2024.12.014 |
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