Lactobacillus acidophilus JCM 1132 strain and its mutant with different bacteriocin-producing behaviour have various in situ effects on the gut microbiota of healthy mice

Wang, Gang, Yu, Yunxia, Garcia-Gutierrez, Enriqueta, Jin, Xing, He, Yufeng, Wang, Linlin, Tian, Peijun, Liu, Zhenmin, Zhao, Jianxin, Zhang, Hao and Chen, Wei (2019) Lactobacillus acidophilus JCM 1132 strain and its mutant with different bacteriocin-producing behaviour have various in situ effects on the gut microbiota of healthy mice. Microorganisms, 8 (1). ISSN 2076-2607

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Abstract

The production of bacteriocin is considered to be a probiotic trait of lactic acid bacteria (LAB). However, not all strains of LAB harbour bacteriocin genes, even within the same species. Moreover, the effects of bacteriocins on the host gut microbiota and on host physiological indicators are rarely studied. This study evaluated the effects of the bacteriocin-producing Lactobacillus acidophilus strain JCM1132 and its non-producing spontaneous mutant, L. acidophilus CCFM720, on the physiological statuses and gut microbiota of healthy mice. Mice that received the bacteriocin-producing strain JCM1132 exhibited reduced water and food intake. Furthermore, the administration of these strains induced significant changes in the compositional abundance of faecal microbiota at the phylum and genus levels, and some of these changes were more pronounced after one week of withdrawal. The effects of CCFM720 treatment on the gut microbiota seemed to favour the prevention of metabolic diseases to some extent. However, individuals that received JCM1132 treatment exhibited weaker inflammatory responses than those that received CCFM720 treatment. Our results indicate that treatment with bacteriocin-producing or non-producing strains can have different effects on the host. Accordingly, this trait should be considered in the applications of LAB.

Item Type:	Article
Additional Information:	Funding information: This work was supported by the National Natural Science Foundation of China (No. 31671839), the National Natural Science Foundation of China Key Program (No. 31530056), the National Natural Science Foundation of China (No. 31301407), the Fundamental Research Funds for the Central Universities (JUSRP51501), a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions, the national first-class discipline program of Food Science and Technology (JUFSTR20180102), the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province, the Natural Science Foundation of Jiangsu Province (BK20180613), the Project funded by China Postdoctoral Science Foundation (2018M642164), the Postdoctoral Science Foundation of Jiangsu Province (2018K090C) and the Walsh Fellowship Project 2015066.
Faculty \ School:	Faculty of Science > School of Biological Sciences
Depositing User:	LivePure Connector
Date Deposited:	03 Mar 2025 15:30
Last Modified:	13 Mar 2025 15:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98636
DOI:	10.3390/microorganisms8010049

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