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ToolsKoemel, Nicholas A., Ahmadi, Matthew N., Biswas, Raaj Kishore, Koster, Annemarie, Atkin, Andrew J., Sabag, Angelo and Stamatakis, Emmanuel (2025) Can incidental physical activity offset the deleterious associations of sedentary behaviour with major adverse cardiovascular events? European Journal of Preventive Cardiology, 32 (1). pp. 77-85. ISSN 2047-4873
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Abstract
Aims Incidental physical activity as part of daily living may offer feasibility advantages over traditional exercise. We examined the joint associations of incidental physical activity and sedentary behaviour with major adverse cardiovascular events (MACE) risk. Methods and results Analyses included 22 368 non-exercising adults from the UK Biobank accelerometry sub-study (median age [IQR]: 62.9 [11.6] years; 41.8% male). Physical activity and sedentary behaviour exposures were derived using a machine learning-based intensity and posture classification schema. We assessed the tertile-based joint associations of sedentary behaviour and the following: a) incidental vigorous (VPA), b) incidental moderate to vigorous (MVPA), c) vigorous intermittent lifestyle physical activity (VILPA; bouts lasting up to 1 min), and d) moderate to vigorous intermittent lifestyle physical activity (MV-ILPA; bouts lasting up to 3 min) with MACE risk. Over an 8.0-year median follow-up, 819 MACE events occurred. Compared to the highest physical activity and lowest sedentary time, high sedentary behaviour (>11.4 h/day) with low incidental VPA (<2.1 min/day) had an HR of 1.34 (95% CI: 0.98, 1.84) and low incidental MVPA (<21.8 min/day) had a 1.89 HR (95% CI: 1.42, 2.52) for MACE. Sedentary behaviour was not associated with MACE at medium and high levels of VPA or VILPA. Completing 4.1 min/day of VPA or VILPA may offset the MACE risk associated with high sedentary behaviour. Conversely, 31–65 min of incidental MVPA or 26–52 min of MV-ILPA per day largely attenuated the associations with MACE. Conclusion Brief intermittent bursts of vigorous incidental physical activity may offset cardiovascular risks from high sedentary behaviour.
| Item Type: | Article |
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| Additional Information: | Data availability statement: The data that support the findings of this study are available from the UK Biobank, but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of the UK Biobank. Funding information: This study is funded by an Australian National Health and Medical Research Council (NHMRC) Investigator Grant (APP 1194510). The funder had no specific role in any of the following study aspects: the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. |
| Uncontrolled Keywords: | cardiovascular disease,cohort studies,lifestyle physical activity,machine learning,mortality,sedentary behaviour,epidemiology,cardiology and cardiovascular medicine,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2713 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > School of Health Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Health Promotion |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 25 Feb 2025 18:30 |
| Last Modified: | 28 Mar 2025 13:13 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98608 |
| DOI: | 10.1093/eurjpc/zwae316 |
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