Structure–function studies of chickpea and durum wheat uncover mechanisms by which cell wall properties influence starch bioaccessibility

Edwards, Cathrina H., Ryden, Peter, Mandalari, Giuseppina, Butterworth, Peter J. and Ellis, Peter R. (2021) Structure–function studies of chickpea and durum wheat uncover mechanisms by which cell wall properties influence starch bioaccessibility. Nature Food, 2 (2). pp. 118-126. ISSN 2662-1355

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Abstract

Positive health effects of dietary fibre have been established; however, the underpinning mechanisms are not well understood. Plant cell walls are the predominant source of fibre in the diet. They encapsulate intracellular starch and delay digestive enzyme ingress, but food processing can disrupt their structure. Here, we compare the digestion kinetics of chickpea (cotyledon) and durum wheat (endosperm), which have contrasting cell wall structures (type I and II, respectively), to investigate a cell wall barrier mechanism that may underpin the health effects of dietary fibre. Using in vitro models, including the dynamic gastric model, to simulate human digestion, together with microscopy, we show that starch bioaccessibility is limited from intact plant cells and that processing treatments can have different effects on cell integrity and digestion kinetics when applied to tissues with contrasting cell wall properties. This new understanding of dietary fibre structure is important for effective fibre supplementation to benefit human health.

Item Type:	Article
Additional Information:	Data availability statement: Source data are provided with this paper. The other datasets generated and/or analysed during the current study are available from the corresponding author upon reasonable request. Funding information: This project was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) (DRINC; BB/H004866/1) and C.H.E. was in receipt of a BBSRC CASE studentship award with Premier Foods (UK) as an industrial partner. C.H.E. gratefully acknowledges support from the BBSRC Institute Strategic Programme Food Innovation and Health (BB/R012512/1) and its constituent project (BBS/E/F/000PR10345).
Uncontrolled Keywords:	food science,animal science and zoology,agronomy and crop science,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1100/1106
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?... https://kclpure.kcl.ac.uk/portal/en/publ...
Depositing User:	LivePure Connector
Date Deposited:	24 Feb 2025 15:30
Last Modified:	28 Mar 2025 13:13
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98572
DOI:	10.1038/s43016-021-00230-y

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