Tools
ToolsLivingstone, Tracey L., Saha, Shikha, Bernuzzi, Federico, Savva, George M., Troncoso-Rey, Perla, Traka, Maria H., Mills, Robert D., Ball, Richard Y. and Mithen, Richard F. (2022) Accumulation of sulforaphane and alliin in human prostate tissue. Nutrients, 14 (16). ISSN 2072-6643
Preview |
PDF (nutrients-14-03263)
- Published Version
Available under License Creative Commons Attribution. Download (3MB) | Preview |
Abstract
Diets rich in cruciferous vegetables have been associated with a lower risk of incidence and progression of prostate cancer. Sulforaphane, an isothiocyanate derived from 4-methylsulphinylbutyl glucosinolate (glucoraphanin) that accumulates in certain of these vegetables, notably broccoli, has been implicated in their protective effects. Likewise, the consumption of garlic and its sulphur-containing compounds such as alliin have been associated with a reduction in risk of prostate cancer. In this study, we tested whether consuming glucoraphanin derived from broccoli seeds and alliin derived from garlic resulted in the occurrence of these potential bioactive compounds in the prostate, which may contribute to our understanding of the putative protective effects of these dietary components. We recruited 42 men scheduled for a trans-perineal prostate biopsy into a randomised, double-blinded, 2 × 2-factorial dietary supplement four-week intervention study, and 39 completed the study. The two active interventions were supplements providing glucoraphanin from broccoli (BroccoMax®) and alliin from garlic (Kwai Heartcare®). Following the intervention, prostate biopsy tissue was analysed for the presence of sulforaphane and its thiol conjugates and for alliin and associated metabolites. Sulforaphane occurred in significantly higher levels in the prostate tissue (both within the transition and peripheral zone) of men consuming the glucoraphanin containing supplements (p < 0.0001) compared to men not consuming these supplements. However, while alliin and alliin-derived metabolites were detected within the prostate, there was no significant difference in the concentrations of these compounds in the prostate of men consuming supplements derived from garlic compared to men not consuming these supplements.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability Statement: Data are available upon request for the corresponding author. Funding Information: The research was supported by the UKRI Biotechnology and Biological Sciences Research Council through Institute Strategic Programme BB/RO12512/1 and by the Prostate Cancer Foundation. G.M.S. was supported by BBSRC Core Capability Grant BB/CCG1860/1. |
| Uncontrolled Keywords: | alliin,broccoli,garlic,glucoraphanin,prostate cancer,sulforaphane,food science,nutrition and dietetics ,/dk/atira/pure/subjectarea/asjc/1100/1106 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > School of Health Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 18 Feb 2025 14:30 |
| Last Modified: | 19 Feb 2025 13:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98539 |
| DOI: | 10.3390/nu14163263 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |