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ToolsAboufarrag, Hassan, Hollands, Wendy J., Percival, Jasmine, Philo, Mark, Savva, George M. and Kroon, Paul A. (2022) No effect of isolated anthocyanins from bilberry fruit and black rice on LDL cholesterol or other biomarkers of cardiovascular disease in adults with elevated cholesterol: A randomized, placebo-controlled, cross-over trial. Molecular Nutrition and Food Research, 66 (21). ISSN 1613-4125
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Abstract
Scope: Some dietary interventions with berry fruits, berry fruit extracts, and purified anthocyanins have been reported to beneficially alter lipoprotein profiles in hyperlipidemic participants. The major anthocyanins in human diets are glycosides of cyanidin and delphinidin, and structure can influence both absorption and bioactivity. The aim of this study is to determine the effects of two major types of anthocyanins on low-density lipoprotein cholesterol and other cardiometabolic markers for cardiovascular disease (CVD) risk in hyperlipidemic individuals. Methods and results: Fifty-two hyperlipidemic participants complete this randomized, placebo-controlled, double-blind, three arm crossover trial. Participants ingest capsules containing 320 mg of anthocyanins (bilberry trihydroxy-type or black rice dihydroxy-type) or placebo once daily for 28 days. Biomarkers of CVD risk are measured before and after the intervention period. Compared to the placebo, neither anthocyanin treatment significantly (p < 0.05) changes circulating levels of lipoproteins (total-/high-density lipoprotein (HDL)-/low-density lipoprotein (LDL)-cholesterol, triglycerides, Apolipoprotein B (ApoB)), biomarkers of glycemic control (fasting glucose, fructosamine), biomarkers of HDL function (ApoA1, HDL3, paraoxonase-1 (PON1) arylesterase, and lactonase activities), or plasma bile acids. Conclusions: These data do not support the notion that regular consumption of anthocyanins beneficially affects glycemic control or lipoprotein profiles or functions. It is possible the no effect observation is due to the relatively short duration of treatments.
| Item Type: | Article |
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| Additional Information: | Data Availability Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request. Funding Information: This research was funded by the BBSRC Institute Strategic Programme Grant Food Innovation and Health BB/R012512/1 and its constituent projects BBS/E/F/000PR10343, BBS/E/F/000PR10346 and BBS/E/F/000PR10347, and by the BBSRC Core Capability Grant BB/CCG1860/1. JP was funded by the BBSRC Norwich Research Park Biosciences Doctoral Training Partnership grant number BB/M011216/1. HA was funded by the Newton-Mosharafa Scholarship Fund from the Egyptian Ministry of Higher Education (Cultural Affairs and Mission Sector), the British Council and the British Embassy in Egypt. |
| Uncontrolled Keywords: | flavonoids,glucose control,low density lipoprotein,paraoxonase-1,vaccinium myrtillus,biotechnology,food science ,/dk/atira/pure/subjectarea/asjc/1300/1305 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > School of Health Sciences Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 18 Feb 2025 14:30 |
| Last Modified: | 18 Feb 2025 14:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98536 |
| DOI: | 10.1002/mnfr.202101157 |
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