Systemic stress signalling: Understanding the cell non-autonomous control of proteostasis

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Taylor, Rebecca C., Berendzen, Kristen M. and Dillin, Andrew (2014) Systemic stress signalling: Understanding the cell non-autonomous control of proteostasis. Nature Reviews Molecular Cell Biology, 15 (3). pp. 211-217. ISSN 1471-0072

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Abstract

Proteome maintenance is crucial to cellular health and viability, and is typically thought to be controlled in a cell-autonomous manner. However, recent evidence indicates that protein-folding defects can systemically activate proteostasis mechanisms through signalling pathways that coordinate stress responses among tissues. Coordination of ageing rates between tissues may also be mediated by systemic modulation of proteostasis. These findings suggest that proteome maintenance is a systemically regulated process, a discovery that may have important therapeutic implications.

Item Type:	Article
Uncontrolled Keywords:	molecular biology,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	13 Feb 2025 18:30
Last Modified:	16 Feb 2025 07:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98495
DOI:	10.1038/nrm3752

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