Analysis of Aging in Caenorhabditis elegans

Wilkinson, Deepti S., Taylor, Rebecca C. and Dillin, Andrew (2012) Analysis of Aging in Caenorhabditis elegans. In: Methods in Cell Biology. Methods in Cell Biology, 107 . Academic Press Inc., pp. 353-381.

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Abstract

This chapter is dedicated to the study of aging in Caenorhabditis elegans (C. elegans). The assays are divided into two sections. In the first section, we describe detailed protocols for performing life span analysis in solid and liquid medium. In the second section, we describe various assays for measuring age-related changes. Our laboratory has been involved in several fruitful collaborations with non- C. elegans researchers keen on testing a role for their favorite gene in modulating aging (Carrano et al., 2009; Dong et al., 2007; Raices et al., 2008; Wolff et al., 2006). But even with the guidance of trained worm biologists, this undertaking can be daunting. We hope that this chapter will serve as a worthy compendium for those researchers who may or may not have immediate access to laboratories studying C. elegans.

Item Type:	Book Section
Uncontrolled Keywords:	abnormality,aging,knockdown,lifespan,muscle decline,survival curve,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1307
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	13 Feb 2025 17:30
Last Modified:	16 Feb 2025 07:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98492
DOI:	10.1016/B978-0-12-394620-1.00012-6

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