Tools
ToolsKajiwara, Hideyuki, Hemmings, Andrew M. and Hirano, Hisashi (1996) Evidence of metal binding activities of pentadecapeptide from Panax ginseng. Journal of Chromatography B: Biomedical Applications, 687 (2). pp. 443-448. ISSN 1572-6495
Full text not available from this repository. (Request a copy)Abstract
A tetradecapeptide from ginseng (Panax ginseng) root showing anti-lipolytic activity in an isolated rat fat cell assay was chemically synthesized for analysis of metal binding activities in vitro. Binding activities against several metal ions were analysed by measuring mobility shifts during capillary zone electrophoresis experiments. The ginseng polypeptide (GPP) showed the greatest increase in effective molecular electrophoretic mobility in the presence of Mg2+. Mobility was also affected in the presence of La3+, Mn2+, Ca2+ and Zn2+ ions. Analysis with the dye Stains-all revealed GPP to possess a cation binding site similar to those in Ca2+-binding proteins. GPP thus appears to be a metal binding peptide. The results of this analysis suggested that GPP may perform its anti-lipolytic activities through an ability to modulate the level of free cellular Mg2+ and Mn2+ ions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | metal binding activity,metal cations,panax ginsens,pentadecapeptide,chemistry(all) ,/dk/atira/pure/subjectarea/asjc/1600 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Plant Sciences Faculty of Science > Research Groups > Molecular Microbiology Faculty of Science > Research Groups > Chemistry of Life Processes Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 13 Feb 2025 17:30 |
| Last Modified: | 16 Feb 2025 06:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98485 |
| DOI: | 10.1016/S0378-4347(96)00240-X |
Actions (login required)
 |
View Item |