The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS

Blundell, Tom L., Lapatto, Risto, Wilderspin, Andrew F., Hemmings, Andrew M., Hobart, Peter M., Danley, Dennis E. and Whittle, Peter J. (1990) The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS. Trends in Biochemical Sciences, 15 (11). pp. 425-430. ISSN 0968-0004

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Abstract

A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.

Item Type:	Article
Uncontrolled Keywords:	biochemistry,molecular biology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1303
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	13 Feb 2025 15:30
Last Modified:	31 Oct 2025 01:09
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98471
DOI:	10.1016/0968-0004(90)90280-O

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