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ToolsBazelmans, Tessel, Arthur, Rowan, Pasco, Greg, Shephard, Elizabeth, Milosavljevic, Bosiljka, Ali, Jannath Begum, Pickles, Andrew, Johnson, Mark H., Jones, Emily J. H. and Charman, Tony and The BASIS/STAARS Team (2024) Mid-childhood autism sibling recurrence in infants with a family history of autism. Autism Research, 17 (7). pp. 1501-1514. ISSN 1939-3792
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Abstract
Autism sibling recurrence in prospective infant family history studies is ~20% at 3 years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3 years and mid-childhood (6 to 12 years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3 years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3 years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3 years. Findings have implications for families and clinical services, and for prospective family history studies.
| Item Type: | Article |
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| Additional Information: | DATA AVAILABILITY STATEMENT: Data available following a review of requests as indicated here: https://www.basisnetwork.org/collaboration-and-project-affiliation/index.html. FUNDING INFORMATION: This research was supported by awards from the Medical Research Council (MR/R011427/1, G0701484, MR/K021389/1, MR/T003057/1), BASIS funding consortium led by Autistica, Autism Speaks. The results leading to this publication have received funding from the Innovative Medicines Initiative Joint Undertaking under grant agreement No 777394 for the project AIMS-2-TRIALS. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA and AUTISM SPEAKS, Autistica, SFARI. Any views expressed are those of the authors and not necessarily those of the funders (IHI-JU2). European Union Horizon Europe grant no. 101057385 (R2D2-MH) and UK Research and Innovation (UKRI) under the UK government's Horizon Europe funding guarantee [grant no.10039383] as part of the Horizon Europe under grant agreement no. 101057385. Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them. Capital equipment funding from the Maudsley Charity (980) and Guy's and St. Thomas’ Charity (STR130505). A. P. acknowledges support from the National Institute for Health Research (NIHR) through NF-SI-0617-10120 and the NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. |
| Uncontrolled Keywords: | autism,diagnosis,family history,infants,recurrence likelihood,siblings,neuroscience(all),clinical neurology,genetics(clinical) ,/dk/atira/pure/subjectarea/asjc/2800 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Social Sciences > School of Psychology |
| UEA Research Groups: | Faculty of Social Sciences > Research Groups > Developmental Science |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 10 Feb 2025 15:30 |
| Last Modified: | 28 Mar 2025 13:12 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98439 |
| DOI: | 10.1002/aur.3182 |
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