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ToolsBazelmans, Tessel, Arthur, Rowan, Pasco, Greg, Shephard, Elizabeth, Milosavljevic, Bosiljka, Ali, Jannath Begum, Pickles, Andrew, Johnson, Mark H., Jones, Emily J. H. and Charman, Tony and The BASIS/STAARS Team (2024) Mid-childhood autism sibling recurrence in infants with a family history of autism. Autism Research, 17 (7). pp. 1501-1514. ISSN 1939-3792
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Abstract
Autism sibling recurrence in prospective infant family history studies is ~20% at 3 years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3 years and mid-childhood (6 to 12 years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3 years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3 years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3 years. Findings have implications for families and clinical services, and for prospective family history studies.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2024 The Author(s). Autism Research published by International Society for Autism Research and Wiley Periodicals LLC. |
| Uncontrolled Keywords: | autism,diagnosis,family history,infants,recurrence likelihood,siblings,neuroscience(all),clinical neurology,genetics(clinical) ,/dk/atira/pure/subjectarea/asjc/2800 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Social Sciences > School of Psychology |
| UEA Research Groups: | Faculty of Social Sciences > Research Groups > Developmental Science |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 10 Feb 2025 15:30 |
| Last Modified: | 17 Feb 2025 15:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98439 |
| DOI: | 10.1002/aur.3182 |
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