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ToolsL'Heurreux, Joanna E., Corbett, Anne, Ballard, Clive, Vauzour, David, Creese, Byron, Winyard, Paul G., Jones, Andrew M. and Vanhatalo, Anni (2025) Oral microbiome and nitric oxide biomarkers in older people with mild cognitive impairment and APOE4 genotype. PNAS Nexus, 4 (1). ISSN 2752-6542
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Abstract
Apolipoprotein E4 (APOE4) genotype and nitric oxide (NO) deficiency are risk factors for age-associated cognitive decline. The oral microbiome plays a critical role in maintaining NO bioavailability during aging. The aim of this study was to assess interactions between the oral microbiome, NO biomarkers, and cognitive function in 60 participants with mild cognitive impairment (MCI) and 60 healthy controls using weighted gene co-occurrence network analysis and to compare the oral microbiomes between APOE4 carriers and noncarriers in a subgroup of 35 MCI participants. Within the MCI group, a high relative abundance of Neisseria was associated with better indices of cognition relating to executive function (Switching Stroop, r s = 0.33, P = 0.03) and visual attention (Trail Making, r s = −0.30, P = 0.05), and in the healthy group, Neisseria correlated with working memory (Digit Span, r s = 0.26, P = 0.04). High abundances of Haemophilus (r s = 0.38, P = 0.01) and Haemophilus parainfluenzae (r s = 0.32, P = 0.03), that co-occurred with Neisseria correlated with better scores on executive function (Switching Stroop) in the MCI group. There were no differences in oral nitrate (P = 0.48) or nitrite concentrations (P = 0.84) between the MCI and healthy groups. Linear discriminant analysis Effect Size identified Porphyromonas as a predictor for MCI and Prevotella intermedia as a predictor of APOE4-carrier status. The principal findings of this study were that a greater prevalence of oral P. intermedia is linked to elevated genetic risk for dementia (APOE4 genotype) in individuals with MCI prior to dementia diagnosis and that interventions that promote the oral Neisseria–Haemophilus and suppress Prevotella-dominated modules have potential for delaying cognitive decline.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability Statement: Sequencing data have been deposited in the National Center for Biotechnology Information Sequence Read Archive Database and are available at BioProject PRJNA1106018. Code used for the analysis is available at https://github.com/jlhxx. |
| Uncontrolled Keywords: | cognitive status,ageing,nitrate,prevotella,genetic risk,cognitive status,genetic risk,aging,nitrate,general,sdg 3 - good health and well-being,3* ,/dk/atira/pure/subjectarea/asjc/1000 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 22 Jan 2025 01:04 |
| Last Modified: | 13 Feb 2025 17:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98288 |
| DOI: | 10.1093/pnasnexus/pgae543 |
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