A Single-Nucleus Atlas of Seed-to-Seed Development in Arabidopsis

Lee, Travis A., Nobori, Tatsuya, Illouz-Eliaz, Natanella, Xu, Jiaying, Jow, Bruce, Nery, Joseph and Ecker, Joseph R. (2023) A Single-Nucleus Atlas of Seed-to-Seed Development in Arabidopsis.

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Abstract

Extensive studies of the reference plant Arabidopsis have enabled a deep understanding of tissues throughout development, yet a census of cell types and states throughout development is lacking. Here, we present a single-nucleus transcriptome atlas of seed-to-seed development employing over 800,000 nuclei, encompassing a diverse set of tissues across ten developmental stages, with spatial transcriptomic validation of the dynamic seed and silique. Cross-organ analyses revealed transcriptional conservation of cell types throughout development and heterogeneity within individual cell types influenced by organ-of-origin and developmental timing, including groups of transcription factors, suggesting gatekeeping by transcription factor activation. This atlas provides a resource for the study of cell type specification throughout the development continuum and a reference for stimulus-response and genetic perturbations at the single-cell resolution.

Item Type:	Article
Faculty \ School:	Faculty of Science > The Sainsbury Laboratory
Depositing User:	LivePure Connector
Date Deposited:	18 Jan 2025 00:39
Last Modified:	28 Jan 2025 23:58
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98249
DOI:

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