Detoxification of nitric oxide by the flavorubredoxin of Salmonella enterica serovar Typhimurium

Mills, P. C., Richardson, D. J. ORCID: https://orcid.org/0000-0002-6847-1832, Hinton, J. C. D. and Spiro, S. (2005) Detoxification of nitric oxide by the flavorubredoxin of Salmonella enterica serovar Typhimurium. Biochemical Society Transactions, 33. pp. 198-199. ISSN 1470-8752

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Abstract

Salmonella possesses multiple enzymes that utilize NO as a substrate, and could therefore contribute to the organism's ability to resist nitrosative killing by macrophages. Flavorubredoxin is an oxygen-sensitive enzyme that reduces NO to nitrous oxide. The Salmonella enterica serovar Typhimurium norV gene encoding flavorubredoxin was disrupted and the NO sensitivity of the mutant was determined. The norV mutant showed a greater sensitivity to NO than wild-type S. Typhimurium, but did recover growth after a transient inhibition. The mutant phenotype suggests that multiple enzymes are employed by S. Typhimurium to detoxify NO under anaerobic conditions, one of which is flavorubredoxin.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Organisms and the Environment Faculty of Science > Research Groups > Molecular Microbiology Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry
Depositing User:	EPrints Services
Date Deposited:	01 Oct 2010 13:37
Last Modified:	24 Sep 2024 09:58
URI:	https://ueaeprints.uea.ac.uk/id/eprint/982
DOI:	10.1042/BST0330198

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