An expert consensus statement on biomarkers of ageing for use in intervention studies

Perri, Giorgia, French, Chloe, Agostinis-Sobrinho, César, Anand, Atul, Antarianto, Radiana Dhewayani, Arai, Yasumichi, Baur, Joseph A., Cauli, Omar, Clivaz-Duc, Morgane, Colloca, Giuseppe, Demetriades, Constantinos, de Lucia, Chiara, Di Gessa, Giorgio, Diniz, Breno S., Dotchin, Catherine L., Eaglestone, Gillian, Elliott, Bradley T., Espeland, Mark A., Ferrucci, Luigi, Fisher, James, Grammatopoulos, Dimitris K., Hardiany, Novi S., Hassan-Smith, Zaki, Hastings, Waylon J., Jain, Swati, Joshi, Peter K., Katsila, Theodora, Kemp, Graham J., Khaiyat, Omid A., Lamming, Dudley W., Gallegos, Jose Lara, Madeo, Frank, Maier, Andrea B., Martin-Ruiz, Carmen, Martins, Ian J., Mathers, John C., Mattin, Lewis R., Merchant, Reshma A., Moskalev, Alexey, Neytchev, Ognian, Ni Lochlainn, Mary, Owen, Claire M., Phillips, Stuart M., Pratt, Jedd, Prokopidis, Konstantinos, Rattray, Nicholas J. W., Rúa-Alonso, María, Schomburg, Lutz, Scott, David, Shyam, Sangeetha, Sillanpää, Elina, Tan, Michelle M. C., Teh, Ruth, Tobin, Stephanie W., Vila-Chã, Carolina J., Vorluni, Luigi, Weber, Daniela, Welch, Ailsa, Wilson, Daisy, Wilson, Thomas, Zhao, Tongbiao, Philippou, Elena, Korolchuk, Viktor I. and Shannon, Oliver M. (2024) An expert consensus statement on biomarkers of ageing for use in intervention studies. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. ISSN 1079-5006

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Abstract

Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method. A three-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of ageing. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of ageing. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70% agreement on a statement/biomarker. Of the 460 international panel members invited to participate, 116 completed Round 1, 87 completed Round 2, and 60 completed Round 3. Across the 3 rounds, 14 biomarkers met consensus that spanned physiological (e.g., insulin-like growth factor 1, growth-differentiating factor-15), inflammatory (e.g., high sensitivity c-reactive protein, interleukin-6), functional (e.g., muscle mass, muscle strength, hand grip strength, Timed-Up-and-Go, gait speed, standing balance test, frailty index, cognitive health, blood pressure), and epigenetic (e.g., DNA methylation/epigenetic clocks) domains. Expert consensus identified 14 potential biomarkers of ageing which may be used as outcome measures in intervention studies. Future ageing research should identify which combination of these biomarkers has the greatest utility.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Related URLs:	https://academic.oup.com/biomedgerontolo...
Depositing User:	LivePure Connector
Date Deposited:	09 Jan 2025 01:03
Last Modified:	13 Jan 2025 01:01
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98121
DOI:	10.1093/gerona/glae297

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