Memory control deficits in the sleep-deprived human brain

Harrington, Marcus O. ORCID: https://orcid.org/0000-0002-6292-7595, Karapanagiotidis, Theodoros, Phillips, Lauryn, Smallwood, Jonathan, Anderson, Michael C. and Cairney, Scott A. (2024) Memory control deficits in the sleep-deprived human brain. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 122 (1). ISSN 0027-8424

Preview

PDF (Harrington_etal_2024_PNAS) - Published Version Available under License Creative Commons Attribution. Download (3MB) | Preview

Abstract

Sleep disturbances are associated with intrusive memories, but the neurocognitive mechanisms underpinning this relationship are poorly understood. Here, we show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep. The functional impairments arising from sleep deprivation are linked to a behavioral deficit in the ability to downregulate unwanted memories, and coincide with a deterioration of deliberate patterns of self-generated thought. We conclude that sleep deprivation gives rise to intrusive memories via the disruption of neural circuits governing mnemonic inhibitory control, which may rely on REM sleep.

Item Type:	Article
Additional Information:	Data, Materials, and Software Availability: Study data is publicly available via the following link: https://osf.io/jfdbx/?view_only=175ffc1f9e9249e09d27612cfcaf62ec (75). Funding information: This work was supported by Medical Research Council Career Development Award No. MR/P020208/1 to S.A.C.
Uncontrolled Keywords:	memory suppression,sleep deprivation,default mode network,heart rate variability,inhibitory control,functional neuroimaging,experimental and cognitive psychology,4* ,/dk/atira/pure/subjectarea/asjc/3200/3205
Faculty \ School:	Faculty of Social Sciences > School of Psychology
Depositing User:	LivePure Connector
Date Deposited:	03 Jan 2025 01:04
Last Modified:	06 Jan 2025 00:59
URI:	https://ueaeprints.uea.ac.uk/id/eprint/98066
DOI:	10.1073/pnas.2400743122

Downloads

Actions (login required)

View Item