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Gall, Alexander, Assadi, Hosamadin S. 
ORCID: https://orcid.org/0000-0002-6143-8095, Li, Rui, Mehmood, Zia, Kasmai, Bahman, Matthews, Gareth ORCID: https://orcid.org/0000-0001-8353-4806 and Garg, Pankaj ORCID: https://orcid.org/0000-0002-5483-169X
(2024)
Estimating coronary sinus oxygen saturation from pulmonary artery oxygen saturation.
Medicina-Lithuania, 60 (11).
ISSN 1010-660X
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Abstract
Background and Objectives: Coronary sinus oxygen saturation is a useful indicator of health and disease states. However, it is not routinely used in clinical practice. Cardiovascular magnetic resonance imaging (CMR) oximetry can accurately estimate oxygen saturation in the pulmonary artery. This research aimed to provide a method for calculating coronary sinus oxygen saturation (ScsO2) from pulmonary artery oxygen saturation (SpaO2) that could be applied to CMR. Materials and Methods: A systematic literature review was conducted to identify prior work that included invasive measures of ScsO2 and either SpaO2 or right ventricular oxygen saturation. This revealed one study with appropriate data (ScsO2 and SpaO2 measurements, n = 18). We then carried out agreement and correlation analyses. Results: Regression analysis demonstrated a statistically significant, positive relationship between ScsO2 and SpaO2, giving a regression equation of ScsO2 = −31.198 + 1.062 × SpaO2 (r = 0.76, p < 0.001). A multivariable regression analysis of all reported variables, excluding SpaO2, independently identified superior vena cava oxygen saturation (SsvcO2) and arterial oxygen saturation (SaO2) as predictors of ScsO2 (r = 0.78, p < 0.001), deriving the equation ScsO2 = −452.8345 + 4.3579 × SaO2 + 0.8537 × SsvcO2. Conclusions: In this study, we demonstrated a correlation between coronary sinus oxygen saturation and pulmonary artery oxygen saturation, allowing the estimation of ScsO2 from SpaO2. This association enables the estimation of ScsO2 from purely CMR-derived data. We have also described a second model using arterial and superior vena cava saturation measurements, providing an alternative method. Future validation in larger, independent cohorts is needed.
| Item Type: | Article |
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| Additional Information: | Data Availability Statement: The original data presented in this study are available in Minerva Anestesiologica at https://www.minervamedica.it/en/journals/minerva-anestesiologica/article.php?cod=R02Y2011N06A0579 (accessed on 11 November 2024), Table 2. These data were derived from the resource available in the public domain at the URL provided. Funding Information: P.G. is funded by the Wellcome Trust Clinical Research Career Development Fellowship (220703/Z/20/Z). G.M. is additionally funded by the National Institute for Health Research (NIHR). The funders had no role in study design, data collection, analysis, publishing decisions, or manuscript preparation. For the purpose of open Access, the authors have applied a CC BY public copyright licence to any Author-Accepted Manuscript version arising from this submission. |
| Uncontrolled Keywords: | cardiac mri,coronary sinus,coronary sinus flow,oxygen saturation,medicine(all) ,/dk/atira/pure/subjectarea/asjc/2700 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 14 Dec 2024 01:40 |
| Last Modified: | 05 Jan 2025 01:18 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97992 |
| DOI: | 10.3390/medicina60111882 |
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