Incidence of hypo- and hyper-capnia in a cross-sectional European cohort of ventilated newborn infants

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van Kaam, Anton H., de Jaegere, Anne P. and Rimensberger, Peter C. and Neovent Study Group (2013) Incidence of hypo- and hyper-capnia in a cross-sectional European cohort of ventilated newborn infants. Archives of Disease in Childhood - Fetal and Neonatal Edition, 98 (4). F323-F326. ISSN 1359-2998

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Abstract

Objective: To determine the incidence of hypo- and hyper-capnia in a European cohort of ventilated newborn infants. Design and setting: Two-point cross-sectional prospective study in 173 European neonatal intensive care units. Patients and methods: Patient characteristics, ventilator settings and measurements, and blood gas analyses were collected for endotracheally ventilated newborn infants on two separate dates. Results: A total of 1569 blood gas analyses were performed in 508 included patients with a mean±SD Pco2 of 48±12 mm Hg or 6.4±1.6 kPa (range 17–104 mm Hg or 2.3–13.9 kPa). Hypocapnia (Pco252 mm Hg or 7 kPa) was present in, respectively, 69 (4%) and 492 (31%) of the blood gases. Hypocapnia was most common in the first 3 days of life (7.3%) and hypercapnia after the first week of life (42.6%). Pco2 was significantly higher in preterm infants (49 mm Hg or 6.5 kPa) than term infants (43 mm Hg or 5.7 kPa) and significantly lower during pressure-limited ventilation (47 mm Hg or 6.3±1.6 kPa) compared with volume-targeted ventilation (51 mm Hg or 6.8±1.7 kPa) and high-frequency ventilation (50 mm Hg or 6.7±1.7 kPa). Conclusions: This study shows that hypocapnia is a relatively uncommon finding during neonatal ventilation. The higher incidence of hypercapnia may suggest that permissive hypercapnia has found its way into daily clinical practice.

Item Type:	Article
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	https://fn.bmj.com/lookup/doi/10.1136/ar...
Depositing User:	LivePure Connector
Date Deposited:	10 Dec 2024 01:46
Last Modified:	16 Dec 2024 01:43
URI:	https://ueaeprints.uea.ac.uk/id/eprint/97960
DOI:	10.1136/archdischild-2012-302649

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