From ocean to emotion: A pilot study exploring acute mood effects following consumption of a DHA-rich powder compared to placebo in middle-aged Australian men

Reddan, Jeffery M., Gauci, Sarah, Young, Lauren M., Kennedy, Greg, Rowsell, Renee, Minihane, Anne-Marie ORCID: https://orcid.org/0000-0001-9042-4226, Scholey, Andrew and Pipingas, Andrew (2024) From ocean to emotion: A pilot study exploring acute mood effects following consumption of a DHA-rich powder compared to placebo in middle-aged Australian men. British Journal of Nutrition. ISSN 0007-1145

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Abstract

There is increasing use of dietary supplements, including omega-3 polyunsaturated fatty acids (ω-3 PUFA) for supporting mental health and mood in the general population. However, despite evidence that ω-3 PUFA may benefit mood over time, data indicating whether a single high dose of ω-3 PUFA can induce acute mood effects are lacking. The present study examined whether a single dose of a docosahexaenoic acid (DHA) rich powder, affects self-reported mood in middle-aged (40 to 60 years) males during elevated cognitive demand. In a randomised, double-blind, placebo-controlled trial with a crossover design, 29 healthy males with a mean age of 52.8 years (SD = 5.3) were administered a powder (incorporated into a meal) containing 4.74 g ω-3 PUFA (DHA 4020 mg; eicosapentaenoic acid 720 mg) or placebo powder in random order on two different testing days separated by a washout period of 7 ± 3 days. On each study day, participants completed mood assessments before and after completing two cognitive test batteries at baseline and again 3.5-4.0 hours following the consumption of the active treatment or placebo. During baseline (i.e., pre-dose) testing, the cognitive batteries increased negative mood (e.g., significantly reduced alertness, increased fatigue, and increased stress). There were similar effects on mood during post-dose testing, but with significant differential treatment effects (i.e., interaction) for alertness (p = 0.008) and stress (p = 0.042). After completing the cognitive batteries, alertness was significantly higher following consumption of the DHA-rich powder compared to placebo (p = 0.006), with a trend towards reduced stress following the consumption of the DHA-rich powder intervention (p = 0.051). Overall, a single high dose of ω-3 PUFA was shown to deliver acute mood benefits following elevated cognitive demand in middle-aged males.

Item Type:	Article
Additional Information:	Funding information: The study was sponsored by Nu-Mega Ingredients Limited, but they did not have any role in the data analysis or interpretation of results.
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Depositing User:	LivePure Connector
Date Deposited:	05 Dec 2024 01:30
Last Modified:	09 Dec 2024 01:38
URI:	https://ueaeprints.uea.ac.uk/id/eprint/97897
DOI:	10.1017/S0007114524002204

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